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Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit

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Rat IL-1 beta/IL-1F2 ELISA Standard Curve
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Summary Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (17 uL), EDTA Plasma (17 uL)
Sensitivity
5 pg/mL
Assay Range
31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma)
Specificity
Natural and recombinant rat IL-1 beta
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Rat IL-1 beta Immunoassay is a 4.5 hour solid phase ELISA designed to measure rat IL-1 beta in cell culture supernates, serum, and EDTA plasma. It contains recombinant rat IL-1 beta and antibodies raised against recombinant rat IL-1 beta. This immunoassay has been shown to quantitate the recombinant rat factor accurately.

Recovery

The recovery of rat IL-1 beta spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=5) 100 89-110
EDTA Plasma (n=5) 98 89-111
Serum (n=5) 108 97-120

Linearity

To assess the linearity of the assay, five or more samples spiked with various concentrations of rat IL-1 beta in each matrix were diluted with Calibrator Diluent and then assayed.
Rat IL-1 beta/IL-1F2 ELISA Linearity

Scientific Data

N/A Rat IL-1 beta/IL-1F2 ELISA Standard Curve View Larger

Rat IL-1 beta/IL-1F2 ELISA Standard Curve

N/A Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit View Larger

Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit Platelet caspase 1 activity and IL‐1 beta secretion in response to CLP. Caspase 1 activity (A) was measured in platelet homogenates obtained from CLP and Sham rats. IL‐1 beta concentration (B) was measured in conditioned media from CLP and Sham rat platelets via ELISA. *P < 0.05 versus Sham. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/31054188), licensed under a CC-BY license. Not internally tested by R&D Systems.

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-1 beta/IL-1F2

The Interleukin 1 (IL-1) family of proteins consists of the classic members IL-1 alpha, IL-1 beta, and IL-1ra, plus IL-18, IL-33, and IL-1F5-10. IL-1 alpha and IL-1 beta bind to the same cell surface receptors and share biological functions (1). IL-1 is not produced by unstimulated cells of healthy mice with the exception of skin keratinocytes, some epithelial cells, and certain cells of the central nervous system. In response to inflammatory agents, infections, or microbial endotoxins, however, a dramatic increase in the production of IL-1 by macrophages and various other cell types is observed. IL-1 beta plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. Inappropriate or prolonged production of IL-1 has been implicated in a variety of pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases (2-5).

 IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both are synthesized as 31 kDa precursors that are subsequently cleaved into mature proteins of approximately 17.5 kDa (6, 7). Cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response (2, 8). Neither IL-1 alpha nor IL-1 beta contains a typical hydrophobic signal peptide (9-11), but evidence suggests that these factors can be secreted by non-classical pathways (12, 13). A portion of unprocessed IL-1 alpha can be presented on the cell membrane and may retain biological activity (14). The precursor form of IL-1 beta, unlike the IL-1 alpha precursor, shows little or no biological activity in comparison to the processed form (13, 15). Both unprocessed and mature forms of IL-1 beta are exported from the cell. 
 IL-1 alpha and IL-1 beta exert their effects through immunoglobulin superfamily receptors that additionally bind IL-1ra. The 80 kDa transmembrane type I receptor (IL-1 RI) is expressed on T cells, fibroblasts, keratinocytes, endothelial cells, synovial lining cells, chondrocytes, and hepatocytes (16, 17). The 68 kDa transmembrane type II receptor (IL-1 RII) is expressed on B cells, neutrophils, and bone marrow cells (18). The two IL-1 receptor types show approximately 28% homology in their extracellular domains but differ significantly in that the type II receptor has a cytoplasmic domain of only 29 amino acids (aa), whereas the type I receptor has a 217 aa cytoplasmic domain. IL-1 RII does not appear to signal in response to IL-1 and may function as a decoy receptor that attenuates IL-1 function (19). The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction (20). IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 (21, 22). Soluble forms of both IL-1 RI and IL-1 RII have been detected in human plasma, synovial fluids, and the conditioned media of several human cell lines (23, 24). In addition, IL-1 binding proteins that resemble soluble IL-1 RII are encoded by vaccinia and cowpox viruses (25).

Long Name:
Interleukin 1 beta
Entrez Gene IDs:
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
Alternate Names:
catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 50 µL Assay Diluent
  3.   Add 50 µL of Assay Diluent to each well.
    4. 50 µL Standard, Control, or Sample
  4.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
  5.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.
    6. 100 µL Conjugate
  6.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
  7.   Aspirate and wash 5 times.
    8. 100 µL Substrate Solution
  8.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
    9. 100 µL Stop Solution
  9.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

158 Citations: Showing 1 - 10
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  1. Development and Characterization of a Cancer Cachexia Rat Model Transplanted with Cells of the Rat Lung Adenocarcinoma Cell Line Sato Lung Cancer (SLC)
    Authors: Kasumi, E;Chiba, M;Kuzumaki, Y;Kuzuoka, H;Sato, N;Takahashi, B;
    Biomedicines
    Species: Rat
    Sample Types: Serum
  2. A novel modified-curcumin 2.24 resolves inflammation by promoting M2 macrophage polarization
    Authors: Deng, J;Golub, LM;Lee, HM;Bhatt, HD;Johnson, F;Xu, TM;Gu, Y;
    Scientific reports
    Species: Rat
    Sample Types: Cell Culture Supernates
  3. Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline
    Authors: Ince, LM;Darling, JS;Sanchez, K;Bell, KS;Melbourne, JK;Davis, LK;Nixon, K;Gaudet, AD;Fonken, LK;
    Brain, behavior, and immunity
    Species: Rat
    Sample Types: Tissue Homogenates
  4. Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats
    Authors: El Gazzar, WB;Sliem, RE;Bayoumi, H;Nasr, HE;Shabanah, M;Elalfy, A;Radwaan, SE;Gebba, MA;Mansour, HM;Badr, AM;Amer, MF;Ashour, SS;Morsi, H;Aboelkomsan, ESAF;Baioumy, B;Sayed, AEH;Farag, AA;
    International journal of molecular sciences
    Species: Rat
    Sample Types: Cell Culture Supernates
  5. Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPAR alpha -dependent manner
    Authors: Bai, Y;Mi, W;Meng, X;Dong, B;Jiang, Y;Lu, Y;Yu, Y;
    BMC neuroscience
    Species: Mouse
    Sample Types: Tissue Homogenates
  6. Therapeutic Effect of Enzymatically Hydrolyzed Cervi Cornu Collagen NP-2007 and Potential for Application in Osteoarthritis Treatment
    Authors: Kim, HR;Lee, SH;Noh, EM;Choi, B;Seo, HY;Jang, H;Kim, SY;Park, MH;
    International journal of molecular sciences
    Species: Rat
    Sample Types: Cell Culture Supernates, Serum
  7. Aqueous cannabidiol ?-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms
    Authors: Changsan, N;Sawatdee, S;Suedee, R;Chunhachaichana, C;Srichana, T;
    International journal of pharmaceutics
    Species: Mouse
    Sample Types: Cell Culture Supernates
  8. Natural antioxidant formula ameliorates lipopolysaccharide-induced impairment of hippocampal neurogenesis and contextual fear memory through suppression of neuroinflammation in rats
    Authors: Zeng, W;Takashima, K;Tang, Q;Zou, X;Ojiro, R;Ozawa, S;Jin, M;Ando, Y;Yoshida, T;Shibutani, M;
    Journal of chemical neuroanatomy
    Species: Rat
    Sample Types: Tissue Homogenates
  9. Artificial nerve graft constructed by coculture of activated Schwann cells and human hair keratin for repair of peripheral nerve defects
    Authors: HJ Qin, H Li, JZ Chen, KR Zhang, XQ Zhao, JQ Qin, B Yu, J Yang
    Neural regeneration research, 2023-05-01;18(5):1118-1123.
    Species: Rat
    Sample Types: Cell Culture Supernates
  10. Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats
    Authors: J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang
    Heliyon, 2023-04-11;9(4):e15333.
    Species: Rat
    Sample Types: Tissue Homogenates
  11. Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway
    Authors: T Yue, X Li, X Chen, T Zhu, W Li, B Wang, C Hang
    Oxidative Medicine and Cellular Longevity, 2023-01-16;2023(0):4383332.
    Species: Rat
    Sample Types: Cell Culture Supernates
  12. Yiyi Fuzi Baijiang Powder Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats via Inhibiting the TLR4/NF-kappaB/NLRP3 Inflammasome Signaling Pathway to Repair the Intestinal Epithelial Barrier, and Modulating Intestinal Microbiota
    Authors: J Yang, L Miao, Y Xue, X Wang
    Oxidative Medicine and Cellular Longevity, 2023-01-14;2023(0):3071610.
    Species: Rat
    Sample Types: Tissue Homogenates
  13. Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats
    Authors: J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang
    Heliyon, 2023;9(4):e15333.
    Species: Rat
    Sample Types: Tissue Homogenates
  14. A Comparative Study of Two Models of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Long-Lasting Accumulation of Corticosterone and Interleukins in the Hippocampus and Frontal Cortex in Koizumi Model
    Authors: MV Onufriev, MY Stepaniche, YV Moiseeva, MY Zhanina, OA Nedogreeva, PA Kostryukov, NA Lazareva, NV Gulyaeva
    Biomedicines, 2022-12-02;10(12):.
    Species: Rat
    Sample Types: Serum
  15. Black Garlic and Thiosulfinate-Enriched Extracts as Adjuvants to Ceftriaxone Treatment in a Rat Peritonitis Model of Sepsis
    Authors: FJ Redondo-Ca, N Bejarano-R, V Baladrón, O Montenegro, LA Gómez, R Velasco, N Villasanti, S Illescas, MT Franco-Ser, I Gracia, JF Rodríguez, JR Muñoz-Rodr, JM Pérez-Orti
    Biomedicines, 2022-12-01;10(12):.
    Species: Rat
    Sample Types: Serum
  16. Targeting caveolae to pump bispecific antibody to TGF-beta into diseased lungs enables ultra-low dose therapeutic efficacy
    Authors: AH Kadam, K Kandasamy, T Buss, B Cederstrom, C Yang, S Narayanapi, J Rodriguez, MD Levin, J Koziol, B Olenyuk, Z Borok, A Chrastina, JE Schnitzer
    PLoS ONE, 2022-11-22;17(11):e0276462.
    Species: Rat
    Sample Types: BALF
  17. Assessing the In Vivo Biocompatibility of Molecularly Imprinted Polymer Nanoparticles
    Authors: S Kassem, SS Piletsky, H Yesilkaya, O Gazioglu, M Habtom, F Canfarotta, E Piletska, AC Spivey, EO Aboagye, SA Piletsky
    Polymers, 2022-10-28;14(21):.
    Species: Rat
    Sample Types: Serum
  18. MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide
    Authors: J Wang, Z Ye, Y Chen, X Qiao, Y Jin
    Scientific Reports, 2022-10-26;12(1):17915.
    Species: Rat
    Sample Types: Plasma
  19. DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model
    Authors: C Liao, H Zhou, H Chen, G Cheng, S Li, F Ma, X Yang, B Xie, W Zhang
    International immunopharmacology, 2022-10-21;113(0):109284.
    Species: Rat
    Sample Types: Cell Culture Supernates
  20. Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways
    Authors: T Khamis, AE Alsemeh, DM Abdullah
    Scientific Reports, 2022-08-27;12(1):14654.
    Species: Rat
    Sample Types: Serum
  21. Rhabdomyolysis-induced acute kidney injury and concomitant apoptosis induction via ROS-mediated ER stress is efficaciously counteracted by epigallocatechin gallate
    Authors: SN Chang, M Haroon, DK Dey, SC Kang
    The Journal of nutritional biochemistry, 2022-08-24;0(0):109134.
    Species: Rat
    Sample Types: Tissue Homogenates
  22. Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor
    Authors: B Chen, G Qin, J Xiao, X Deng, A Lin, H Liu
    Journal of Neuroinflammation, 2022-07-13;19(1):181.
    Species: Rat
    Sample Types: Serum
  23. N-3 PUFA Ameliorates the Gut Microbiota, Bile Acid Profiles, and Neuropsychiatric Behaviours in a Rat Model of Geriatric Depression
    Authors: TH Tung, YC Chen, YT Lin, SY Huang
    Biomedicines, 2022-07-04;10(7):.
    Species: Rat
    Sample Types: Plasma
  24. PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression
    Authors: Y Bai, Q Han, B Dong, H Lin, Y Jiang, X Zhang, H Chen, Y Yu
    Brain research bulletin, 2022-03-30;184(0):56-67.
    Species: Mouse
    Sample Types: Tissue Homogenates
  25. Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis?fibroblast?like synoviocytes by inhibiting the NF?kappaB and MAPK signaling pathways
    Authors: X Gao, X Kang, H Lu, E Xue, R Chen, J Pan, J Ma
    Molecular Medicine Reports, 2022-03-24;25(5):.
    Species: Rat
    Sample Types: Serum
  26. A Comparative Study of Koizumi and Longa Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Early Corticosterone and Inflammatory Response in the Hippocampus and Frontal Cortex
    Authors: MV Onufriev, YV Moiseeva, MY Zhanina, NA Lazareva, NV Gulyaeva
    International Journal of Molecular Sciences, 2021-12-17;22(24):.
    Species: Rat
    Sample Types: Serum
  27. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties
    Authors: MG Frank, KH Nguyen, JB Ball, S Hopkins, T Kelley, MV Baratta, M Fleshner, SF Maier
    Brain, Behavior, and Immunity, 2021-12-13;100(0):267-277.
    Species: Rat
    Sample Types: Tissue Homogenates
  28. Protective effects of endothelial progenitor cell microvesicles on Ang�II?induced rat kidney cell injury
    Authors: Y Song, Z Bai, Y Zhang, J Chen, M Chen, Y Zhang, X Zhang, H Mai, B Wang, Y Lin, S Gu
    Molecular Medicine Reports, 2021-11-05;25(1):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  29. Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP)
    Authors: B Sun, Z Chen, Q Chi, Y Zhang, B Gao
    Journal of Cellular and Molecular Medicine, 2021-10-13;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  30. Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats
    Authors: YC Cheng, YM Chiu, ZK Dai, BN Wu
    Cells, 2021-10-08;10(10):.
    Species: Rat
    Sample Types: Plasma
  31. Protective effect of parecoxib sodium against ischemia reperfusion?induced intestinal injury
    Authors: M Li, Z Zheng
    Molecular Medicine Reports, 2021-09-09;24(5):.
    Species: Rat
    Sample Types: Tissue Homogenates
  32. GPER and IGF-1R mediate the anti-inflammatory effect of genistein against lipopolysaccharide (LPS)-induced nigrostriatal injury in rats
    Authors: ZR Du, Y Gu, XM Xie, M Zhang, GY Jiang, WF Chen
    The Journal of steroid biochemistry and molecular biology, 2021-08-31;214(0):105989.
    Species: Rat
    Sample Types: Tissue Homogenates
  33. Prenatal Hyperhomocysteinemia Induces Glial Activation and Alters Neuroinflammatory Marker Expression in Infant Rat Hippocampus
    Authors: AD Shcherbits, DS Vasilev, YP Milyutina, NL Tumanova, AV Mikhel, IV Zalozniaia, AV Arutjunyan
    Cells, 2021-06-18;10(6):.
    Species: Rat
    Sample Types: Tissue Homogenates
  34. Down-regulation of SNHG16 alleviates the acute lung injury in sepsis rats through miR-128-3p/HMGB3 axis
    Authors: J Sun, K Xin, C Leng, J Ge
    BMC pulmonary medicine, 2021-06-06;21(1):191.
    Species: Rat
    Sample Types: Tissue Homogenates
  35. MiR-128-3p alleviates TNBS-induced colitis through inactivating TRAF6/NF-&kappaB signaling pathway in rats
    Authors: LL Huo, ZR Sun
    The Kaohsiung journal of medical sciences, 2021-05-27;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  36. Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen-Glucose Deprivation-Induced Ischemic Neuronal Injury
    Authors: DP Wang, KY Jin, P Zhao, Q Lin, K Kang, J Hai
    International Journal of Nanomedicine, 2021-05-27;16(0):3661-3678.
    Species: Rat
    Sample Types: Cell Culture Supernates
  37. Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-&kappaB signaling pathway
    Authors: H Gao, H Ma, M Gao, A Chen, S Zha, J Yan
    Bioscience Reports, 2021-04-30;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  38. Protective effects of curcumin against rat intestinal inflammation?related motility disorders
    Authors: Y Yao, R Luo, S Xiong, C Zhang, Y Zhang
    Molecular Medicine Reports, 2021-03-24;23(5):.
    Species: Rat
    Sample Types: Serum
  39. Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats
    Authors: EK Jackson, Z Mi, DG Gillespie, D Cheng, SP Tofovic
    Journal of the American Heart Association, 2021-03-08;10(6):e020088.
    Species: Rat
    Sample Types: Plasma
  40. Vagus nerve stimulation ameliorates L-NAME-induced preeclampsia-like symptoms in rats through inhibition of the inflammatory response
    Authors: L Zheng, R Tang, L Shi, M Zhong, Z Zhou
    BMC pregnancy and childbirth, 2021-03-04;21(1):177.
    Species: Rat
    Sample Types: Serum
  41. Sericin-chitosan-glycosaminoglycans hydrogels incorporated with growth factors for in vitro and in vivo skin repair
    Authors: S Sapru, S Das, M Mandal, AK Ghosh, SC Kundu
    Carbohydrate polymers, 2021-01-29;258(0):117717.
    Species: Rat
    Sample Types: Serum
  42. Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin
    Authors: CR Muller, V Courelli, A Lucas, AT Williams, JB Li, F Dos Santos, CT Cuddington, SR Moses, AF Palmer, EB Kistler, P Cabrales
    Scientific Reports, 2021-01-28;11(1):2509.
    Species: Rat
    Sample Types: Plasma
  43. P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-&kappaB/NLRP3 Crosstalk
    Authors: Z Li, Z Huang, H Zhang, J Lu, Y Tian, Y Wei, Y Yang, L Bai
    Oxidative Medicine and Cellular Longevity, 2021-01-16;2021(0):8868361.
    Species: Rat
    Sample Types: Cell Culture Supernates
  44. Central Administration of Angiotensin-(1-7) Improves Vasopressin Impairment and Hypotensive Response in Experimental Endotoxemia
    Authors: P Passaglia, F de Lima Fa, ME Batalhão, AM Stabile, LM Bendhack, J Antunes-Ro, R Lacchini, E Capellari
    Cells, 2021-01-08;10(1):.
    Species: Rat
    Sample Types: Serum
  45. Isoflurane reduces septic neuron injury by HO?1?mediated abatement of inflammation and apoptosis
    Authors: L Zhang, X Zhang, T Wu, X Pan, Z Wang
    Molecular Medicine Reports, 2020-12-23;23(2):.
    Species: Mouse
    Sample Types: Serum
  46. Continuous administration of a p38&alpha inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level
    Authors: JJ Alam, M Krakovsky, U Germann, A Levy
    PLoS ONE, 2020-12-04;15(12):e0233073.
    Species: Rat
    Sample Types: Tissue Culture Supernates
  47. Sex Differences in Vagus Nerve Stimulation Effects on Rat Cardiovascular and Immune Systems
    Authors: F Yaghouby, K Jang, U Hoang, S Asgari, S Vasudevan
    Front Neurosci, 2020-11-06;14(0):560668.
    Species: Rat
    Sample Types: Plasma
  48. Substrate Elasticity Exerts Functional Effects on Primary Microglia
    Authors: SJ Blaschke, S Demir, A König, JA Abraham, SU Vay, M Rabenstein, DN Olschewski, C Hoffmann, M Hoffmann, N Hersch, R Merkel, B Hoffmann, M Schroeter, GR Fink, MA Rueger
    Front Cell Neurosci, 2020-11-05;14(0):590500.
    Species: Rat
    Sample Types: Cell Culture Supernates
  49. SNHG16 aggravates chronic constriction injury-induced neuropathic pain in rats via binding with miR-124-3p and miR-141-3p to upregulate JAG1
    Authors: H Li, L Fan, Y Zhang, Y Cao, X Liu
    Brain Res Bull, 2020-10-10;165(0):228-237.
    Species: Rat
    Sample Types: Cell Culture Supernates
  50. Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways
    Authors: L Jia, K Xue, J Liu, OA Habotta, L Hu, AE Abdel Mone
    Mediators Inflamm, 2020-09-29;2020(0):9419085.
    Species: Rat
    Sample Types: Cell Culture Supernates
  51. Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway
    Authors: C Huang, W Zhang, A Sun, X Zhang, J Guo, R Ji, L Qiao, X Sun, D Zhao
    Oxid Med Cell Longev, 2020-08-18;2020(0):7075836.
    Species: Rat
    Sample Types: Cell Culture Supernates
  52. N?acetyl cysteine inhibits the lipopolysaccharide?induced inflammatory response in bone marrow mesenchymal stem cells by suppressing the TXNIP/NLRP3/IL?1&beta signaling pathway
    Authors: X Wang, M Jiang, X He, B Zhang, W Peng, L Guo
    Molecular Medicine Reports, 2020-08-13;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  53. Inhibitor of RAGE and glucose?induced inflammation in bone marrow mesenchymal stem cells: Effect and mechanism of action
    Authors: M Jiang, X Wang, P Wang, W Peng, B Zhang, L Guo
    Molecular Medicine Reports, 2020-08-07;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  54. Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide?induced acute pneumonia in rats
    Authors: X Wang
    Molecular Medicine Reports, 2020-08-04;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  55. Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats
    Authors: YN Chen, HH Sha, YW Wang, Q Zhou, P Bhuiyan, NN Li, YN Qian, HQ Dong
    J Neuroinflammation, 2020-07-22;17(1):217.
    Species: Rat
    Sample Types: Cell Culture Supernates
  56. Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock?resuscitation?induced acute lung injury through inhibiting the NLRP3 inflammasome
    Authors: T Ming, M Yuan, Q Kong, Q Huang, Z Xia, X Wu
    Mol Med Rep, 2020-07-10;22(3):2507-2515.
    Species: Rat
    Sample Types: Serum
  57. PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation
    Authors: D Hirohama, W Kawarazaki, M Nishimoto, N Ayuzawa, T Marumo, S Shibata, T Fujita
    Int J Mol Sci, 2020-06-22;21(12):.
    Species: Rat
    Sample Types: Tissue Homogenates
  58. Anti?inflammatory activity of 3,5,6,7,3',4'?hexamethoxyflavone via repression of the NF?&kappaB and MAPK signaling pathways in LPS?stimulated RAW264.7 cells
    Authors: ES Son, JW Park, SH Kim, HR Park, W Han, OC Kwon, JY Nam, SH Jeong, CS Lee
    Mol Med Rep, 2020-06-18;22(3):1985-1993.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  59. NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture
    Authors: DC Cornelius, OK Travis, RW Tramel, M Borges-Rod, CH Baik, M Greer, CA Giachelli, GA Tardo, JM Williams
    PLoS ONE, 2020-06-17;15(6):e0234039.
    Species: Rat
    Sample Types: Plasma
  60. Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis
    Authors: O Ameen, RI Yassien, YM Naguib
    BMC Musculoskelet Disord, 2020-06-12;21(1):375.
    Species: Rat
    Sample Types: Serum
  61. Long non-coding RNA ANRIL knockdown suppresses apoptosis and pro-inflammatory cytokines while enhancing neurite outgrowth via binding microRNA-125a in a cellular model of Alzheimer's disease
    Authors: B Zhou, L Li, X Qiu, J Wu, L Xu, W Shao
    Mol Med Rep, 2020-06-02;22(2):1489-1497.
    Species: Rat
    Sample Types: Cell Culture Supernates
  62. Dietary Saturated Fatty Acids Modulate Pain Behaviour in Trauma-Induced Osteoarthritis in Rats
    Authors: S Sekar, SK Panchal, NK Ghattamane, L Brown, R Crawford, Y Xiao, I Prasadam
    Nutrients, 2020-02-18;12(2):.
    Species: Rat
    Sample Types: Plasma
  63. Comparison of the acute toxicity, analgesic and anti-inflammatory activities and chemical composition changes in Rhizoma anemones Raddeanae caused by vinegar processing
    Authors: SS Wang, SY Zhou, XY Xie, L Zhao, Y Fu, GZ Cai, JY Gong
    BMC Complement Med Ther, 2020-01-15;20(1):7.
    Species: Rat
    Sample Types: Serum
  64. Identification of microRNA?363?3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53?signaling pathway
    Authors: M Zhang, Z Wang, B Li, F Sun, A Chen, M Gong
    Mol Med Rep, 2020-01-14;21(3):1077-1088.
    Species: Rat
    Sample Types: Synovial Fluid
  65. Moderate-intensity physical activity reduces systemic inflammation and maintains cardiorespiratory function following chronic particulate matter2.5 exposure in rats
    Authors: A van Wavere, MJ Duncan, F Coulson, A Fenning
    Toxicol Rep, 2019-12-17;7(0):93-100.
    Species: Rat
    Sample Types: Serum
  66. Hemorrhagic Shock Sensitized the Diaphragm to Ventilator-Induced Dysfunction through the Activation of IL-6/JAK/STAT Signaling-Mediated Autophagy in Rats
    Authors: LJ Zhang, SZ Ni, XL Zhou, Y Zhao
    Mediators Inflamm., 2019-11-14;2019(0):3738409.
    Species: Rat
    Sample Types: Tissue Homogenates
  67. Neutrophil activation causes tumor regression in Walker 256 tumor-bearing rats
    Authors: WMT Kuwabara, J Andrade-Si, JNB Pereira, JH Scialfa, J Cipolla-Ne
    Sci Rep, 2019-11-11;9(1):16524.
    Species: Rat
    Sample Types: BALF
  68. Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model
    Authors: CC Hsiao, CC Lin, YS Hou, JY Ko, CJ Wang
    Int J Mol Sci, 2019-10-05;20(19):.
    Species: Rat
    Sample Types: Tissue Lysates
  69. Nrf2 Suppression Delays Diabetic Wound Healing Through Sustained Oxidative Stress and Inflammation
    Authors: M Li, H Yu, H Pan, X Zhou, Q Ruan, D Kong, Z Chu, H Li, J Huang, X Huang, A Chau, W Xie, Y Ding, P Yao
    Front Pharmacol, 2019-09-20;10(0):1099.
    Species: Rat
    Sample Types: Serum
  70. Low-Energy Extracorporeal Shock Wave Therapy Ameliorates Kidney Function in Diabetic Nephropathy
    Authors: CC Hsiao, WH Huang, KH Cheng, CT Lee
    Oxid Med Cell Longev, 2019-07-04;2019(0):8259645.
    Species: Rat
    Sample Types: Tissue Lysate
  71. Sex-specific maternofetal innate immune responses triggered by group B Streptococci
    Authors: MJ Allard, A Giraud, M Segura, G Sebire
    Sci Rep, 2019-06-13;9(1):8587.
    Species: Rat
    Sample Types: Protein
  72. Ascorbic acid deficiency increases hepatic expression of acute phase proteins through the intestine-derived IL-6 and hepatic STAT3 pathway in ODS rats
    Authors: N Kawade, A Murai, W Suzuki, Y Tokuda, M Kobayashi, F Horio
    J. Nutr. Biochem., 2019-05-14;70(0):116-124.
    Species: Rat
    Sample Types: Serum
  73. NLRP3 inflammasome activation in platelets in response to sepsis
    Authors: DC Cornelius, CH Baik, OK Travis, DL White, CM Young, W Austin Pie, CA Shields, B Poudel, JM Williams
    Physiol Rep, 2019-05-01;7(9):e14073.
    Species: Rat
    Sample Types: Plasma
  74. Atractylenolide III Attenuates Muscle Wasting in Chronic Kidney Disease via the Oxidative Stress-Mediated PI3K/AKT/mTOR Pathway
    Authors: M Wang, R Hu, Y Wang, L Liu, H You, J Zhang, X Wu, T Pei, F Wang, L Lu, W Xiao, L Wei
    Oxid Med Cell Longev, 2019-04-18;2019(0):1875471.
    Species: Rat
    Sample Types: Serum
  75. Anti-inflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation
    Authors: YJ Chen, CC Hsu, YJ Shiao, HT Wang, YL Lo, AMY Lin
    Sci Rep, 2019-02-21;9(1):2516.
    Species: Rat
    Sample Types: Cell Culture Supernates
  76. Neuroinflammation induced by the peptide amyloid-? (25-35) increase the presence of galectin-3 in astrocytes and microglia and impairs spatial memory
    Authors: E Ramírez, C Sánchez-Ma, MA Mayoral, L Mendieta, V Alatriste, A Patricio-M, ID Limón
    Neuropeptides, 2019-02-14;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  77. Hepatokine ?1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction
    Authors: D Hakuno, M Kimura, S Ito, J Satoh, Y Nakashima, T Horie, Y Kuwabara, M Nishiga, Y Ide, O Baba, H Nishi, T Nakao, T Nishino, F Nakazeki, S Koyama, R Hanada, RR Randolph, J Endo, T Kimura, K Ono
    Sci Rep, 2018-11-13;8(1):16749.
    Species: Rat
    Sample Types: Cell Culture Supernates
  78. Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model
    Authors: JY Chen, LW Chu, KI Cheng, SL Hsieh, YS Juan, BN Wu
    Sci Rep, 2018-11-07;8(1):16457.
    Species: Rat
    Sample Types: Tissue Homogenates
  79. MiR-10 targets NgR to modulate the proliferation of microglial cells and the secretion of inflammatory cytokines
    Authors: W Wang, R Zhan, J Zhou, J Wang, S Chen
    Exp. Mol. Pathol., 2018-10-09;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  80. Local Delivery of ?-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury
    Authors: J Wang, H Li, Y Ren, Y Yao, J Hu, M Zheng, Y Ding, YY Chen, Y Shen, LL Wang, Y Zhu
    Cell. Physiol. Biochem., 2018-08-30;49(2):595-609.
    Species: Rat
    Sample Types: Tissue Homogenates
  81. Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury
    Authors: D Li, W Ren, Z Jiang, L Zhu
    Mol Med Rep, 2018-08-24;0(0):.
    Species: Mouse
    Sample Types: BALF
  82. Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats
    Authors: H Guo, L Sun, S Ling, JW Xu
    Mediators Inflamm., 2018-08-12;2018(0):7304096.
    Species: Rat
    Sample Types: Serum
  83. Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine
    Authors: MRH Dutra, RDS Feliciano, KR Jacinto, TLF Gouveia, E Brigidio, AJ Serra, M Morris, MDG Naffah-Maz, JA Silva
    Oxid Med Cell Longev, 2018-08-06;2018(0):6736721.
    Species: Rat
    Sample Types: Tissue Homogenates
  84. Cobra Venom Factor-induced complement depletion protects against lung ischemia reperfusion injury through alleviating blood-air barrier damage
    Authors: C Haihua, W Wei, H Kun, L Yuanli, L Fei
    Sci Rep, 2018-07-09;8(1):10346.
    Species: Rat
    Sample Types: BALF
  85. Autophagy mediates tumor necrosis factor-?-induced phenotype switching in vascular smooth muscle A7r5 cell line
    Authors: M García-Mig, JA Riquelme, I Norambuena, PE Morales, F Sanhueza-O, C Nuñez-Soto, D Mondaca-Ru, N Cancino-Ar, A San Martín, M Chiong
    PLoS ONE, 2018-05-11;13(5):e0197210.
    Species: Rat
    Sample Types: Cell Culture Supernates
  86. Chronic agomelatine treatment prevents comorbid depression in the post-status epilepticus model of acquired epilepsy through suppression of inflammatory signaling
    Authors: J Tchekalaro, D Atanasova, L Kortenska, M Atanasova, N Lazarov
    Neurobiol. Dis., 2018-04-10;115(0):127-144.
    Species: Rat
    Sample Types: Plasma
  87. Anti-inflammatory effect of Mongolian drug Naru-3 on traumatic spinal cord injury and its mechanism of action
    Authors: B Baiyila, B He, G He, T Long
    J. Int. Med. Res., 2018-04-03;0(0):3000605187601.
    Species: Rat
    Sample Types: Serum
  88. The local cytokine and growth factor response to rhBMP-2 after spinal fusion
    Authors: JD Koerner, DZ Markova, GD Schroeder, BP Calio, A Shah, CW Brooks, AR Vaccaro, DG Anderson, CK Kepler
    Spine J, 2018-03-14;0(0):.
    Species: Rat
    Sample Types: Tissue Lysates
    Applications: ELISA (Standard)
  89. Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders
    Authors: S Hagan, MCT Fyfe, B Ofori-Frim, K Oliver, MR Foster, S Sirohi, Y Solanke, M Doughty, A Rowley, M Taylor, S Webber, CA Walshe
    Invest. Ophthalmol. Vis. Sci., 2018-03-01;59(3):1443-1453.
    Species: Rat
    Sample Types: Tissue Homogenates
  90. Short-term inhalation study of graphene oxide nanoplates
    Authors: YH Kim, MS Jo, JK Kim, JH Shin, JE Baek, HS Park, HJ An, JS Lee, BW Kim, HP Kim, KH Ahn, K Jeon, SM Oh, JH Lee, T Workman, EM Faustman, IJ Yu
    Nanotoxicology, 2018-02-01;0(0):1-15.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ELISA Capture
  91. Ablation of the Right Cardiac Vagus Nerve Reduces Acetylcholine Content without Changing the Inflammatory Response during Endotoxemia
    Authors: K Plaschke, TQM Do, F Uhle, T Brenner, MA Weigand, J Kopitz
    Int J Mol Sci, 2018-02-01;19(2):.
    Species: Rat
    Sample Types: Plasma
  92. Green tea extract attenuates LPS-induced retinal inflammation in rats
    Authors: JL Ren, QX Yu, WC Liang, PY Leung, TK Ng, WK Chu, CP Pang, SO Chan
    Sci Rep, 2018-01-11;8(1):429.
    Species: Rat
    Sample Types: Vitreous Humor
  93. Ferulaldehyde Improves the Effect of Methotrexate in Experimental Arthritis
    Authors: L Slovák, K Švík, D Mihalová, J Tóth, S Czigle, ? Pašková, F Bilka, K Bauerová
    Molecules, 2017-11-06;22(11):.
    Species: Rat
    Sample Types: Plasma
  94. Electroacupuncture serum inhibits TNF???mediated chondrocyte inflammation via the Ras?Raf?MEK1/2?ERK1/2 signaling pathway
    Authors: H Chen, X Shao, L Li, C Zheng, X Xu, X Hong, X Li, M Wu
    Mol Med Rep, 2017-08-28;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  95. Short-term treatment with taurolidine is associated with liver injury
    Authors: R Fahrner, A Möller, AT Press, A Kortgen, M Kiehntopf, F Rauchfuss, U Settmacher, AS Mosig
    BMC Pharmacol Toxicol, 2017-08-11;18(1):61.
    Species: Rat
    Sample Types: Serum
  96. Oral Administration of Red Ginseng Extract Promotes Neurorestoration after Compressive Spinal Cord Injury in Rats
    Authors: P Zhu, K Samukawa, H Fujita, H Kato, M Sakanaka
    Evid Based Complement Alternat Med, 2017-07-30;2017(0):1265464.
    Species: Rat
    Sample Types: Tissue Homogenates
  97. Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system
    Authors: K Yan, Y Shen
    Mol Med Rep, 2017-07-28;0(0):.
    Species: Rat
    Sample Types: Serum
  98. Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate?induced osteoarthritis rats
    Authors: JW Jeong, HH Lee, J Kim, EO Choi, H Hwang-Bo, HJ Kim, MY Kim, KI Ahn, GY Kim, KW Lee, KY Kim, SG Kim, SH Hong, C Park, HJ Cha, YH Choi
    Mol Med Rep, 2017-07-21;0(0):.
    Species: Rat
    Sample Types: Serum
  99. Innate And Adaptive Immunity are Progressively Activated in Parallel with Renal Injury in the 5/6 Renal Ablation Model
    Authors: C Fanelli, SCA Arias, FG Machado, JK Okuma, DMAC Malheiros, H Azevedo, CA Moreira-Fi, NOS Camara, CK Fujihara, R Zatz
    Sci Rep, 2017-06-09;7(1):3192.
    Species: Rat
    Sample Types: Tissue Homogenates
  100. Neuroprotective effects of food restriction on autonomic innervation of the lacrimal gland in rat
    Authors: HZ Nooh, NH El-Saify, NMN Eldien
    Ann. Anat., 2017-05-24;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  101. Pharmacologic targeting ERK1/2 attenuates the development and progression of hyperuricemic nephropathy in rats
    Authors: N Liu, L Xu, Y Shi, L Fang, H Gu, H Wang, X Ding, S Zhuang
    Oncotarget, 2017-05-16;8(20):33807-33826.
    Species: Rat
    Sample Types: Tissue Culture Supernates
  102. Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model
    Authors: F Chen, H Li, G Zhu, X Chen, Z Tang
    Mol Med Rep, 2017-05-11;0(0):.
    Species: Rat
    Sample Types: Serum
  103. Anti-aging effect and gene expression profiling of dung beetle glycosaminoglycan in aged rats
    Authors: MY Ahn, BJ Kim, HJ Kim, JS Hwang, YS Jung, KK Park
    Biomater Res, 2017-04-21;21(0):5.
    Species: Rat
    Sample Types: Serum
  104. Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences
    Authors: JE Finnell, CM Lombard, AR Padi, CM Moffitt, LB Wilson, CS Wood, SK Wood
    PLoS ONE, 2017-02-27;12(2):e0172868.
    Species: Rat
    Sample Types: Tissue Homogenates
  105. Investigation of the effect of phlomisoside F on complete Freund's adjuvant-induced arthritis
    Authors: X Zhang, Y Dong, H Dong, W Zhang, F Li
    Exp Ther Med, 2016-12-22;13(2):710-716.
    Species: Rat
    Sample Types: Serum
  106. The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain
    Authors: Chi-Hua Guo
    Int. J. Mol. Med, 2016-09-30;38(5):1433-1442.
    Species: Rat
    Sample Types: Tissue Homogenates
  107. Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor
    J Neurosci, 2016-07-06;36(27):7095-108.
    Species: Rat
    Sample Types: Tissue Homogenates
  108. Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration.
    Authors: Jiao H, Natoli R, Valter K, Provis J, Rutar M
    PLoS ONE, 2015-12-02;10(12):e0143952.
    Species: Rat
    Sample Types: Tissue Homogenates
  109. Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain.
    Authors: Tang J, Zhu C, Li Z, Liu X, Sun S, Zhang T, Luo Z, Zhang H, Li W
    J Neuroinflammation, 2015-03-25;12(0):57.
    Species: Rat
    Sample Types: Tissue Homogenates
  110. Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.
    Authors: Fu H, Yang T, Xiao W, Fan L, Wu Y, Terrando N, Wang T
    PLoS ONE, 2014-08-29;9(8):e106331.
    Species: Rat
    Sample Types: Serum
  111. Catalpol ameliorates sodium taurocholate-induced acute pancreatitis in rats via inhibiting activation of nuclear factor kappa B.
    Authors: Xiao W, Yin G, Fan Y, Qiu L, Cang X, Yu G, Hu Y, Xing M, Wu D, Wang X, Hu G, Wan R
    Int J Mol Sci, 2014-07-04;15(7):11957-72.
    Species: Rat
    Sample Types: Serum
  112. Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells.
    Authors: Ramos P, Rubies C, Torres M, Batlle M, Farre R, Brugada J, Montserrat J, Almendros I, Mont L
    Respir Res, 2014-04-28;15(0):54.
    Species: Rat
    Sample Types: Plasma
  113. Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood-spinal cord barrier following ischemia/reperfusion injury in rats.
    Authors: Li X, Wang J, Fang B, Tan W, Ma H
    Mol Brain, 2014-04-21;7(0):28.
    Species: Rat
    Sample Types: Tissue Homogenates
  114. Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury.
    Authors: Li Z, Li J, Wang L, Zhang J, Wu J, Mao X, Shi G, Wang Q, Wang F, Zou J
    J Neuroinflammation, 2014-04-05;11(0):71.
    Species: Rat
    Sample Types: Cell Culture Supernates
  115. Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat.
    Authors: Wang Z, Huang W, Zuo Z
    J Neuroinflammation, 2014-03-25;11(0):56.
    Species: Rat
    Sample Types: Whole Tissue
  116. Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: gastroprotective and ulcer healing properties in rats.
    Authors: Maria-Ferreira D, da Silva L, Mendes D, Cabrini D, Nascimento A, Iacomini M, Cipriani T, Santos A, Werner M, Baggio C
    PLoS ONE, 2014-01-08;9(1):e84762.
    Species: Rat
    Sample Types: Tissue Culture Supernates
  117. Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model.
    Authors: Ding N, Wang F, Xiao H, Xu L, She S
    PLoS ONE, 2013-09-10;8(9):e74633.
    Species: Rat
    Sample Types: BALF
  118. A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion.
    Cytokine, 2012-12-23;61(2):614-21.
    Species: Rat
    Sample Types: BALF
  119. Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain.
    J Neuroinflammation, 2012-07-23;9(0):181.
    Species: Rat
    Sample Types: Tissue Homogenates
  120. Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.
    Authors: Kaldunski M, Jia S, Geoffrey R, Basken J, Prosser S, Kansra S, Mordes JP, Lernmark A, Wang X, Hessner MJ
    Diabetes, 2010-08-03;59(10):2375-85.
    Species: Rat
    Sample Types: Cell Culture Supernates
  121. Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury.
    Authors: Calvo M, Zhu N, Tsantoulas C, Ma Z, Grist J, Loeb JA, Bennett DL
    J. Neurosci., 2010-04-14;30(15):5437-50.
    Species: Rat
    Sample Types: Cell Culture Supernates
  122. Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
    Authors: Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR
    Neuroscience, 2010-01-20;165(2):569-83.
    Species: Rat
    Sample Types: CSF
  123. House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
    Authors: De Alba J, Raemdonck K, Dekkak A, Collins M, Wong S, Nials AT, Knowles RG, Belvisi MG, Birrell MA
    Eur. Respir. J., 2009-10-19;35(6):1377-87.
    Species: Rat
    Sample Types: BALF
  124. Peripheral osmotic stimulation inhibits the brain's innate immune response to microdialysis of acidic perfusion fluid adjacent to supraoptic nucleus.
    Authors: Summy-Long JY, Hu S
    Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009-09-16;297(5):R1532-45.
    Species: Rat
    Sample Types: Plasma
  125. In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland.
    Authors: Sanchez-Lemus E, Benicky J, Pavel J, Saavedra JM
    Brain Behav. Immun., 2009-05-07;23(7):945-57.
    Species: Rat
    Sample Types: Tissue Homogenates
  126. Role of sensory innervation in the rat pulmonary neutrophil recruitment induced by staphylococcal enterotoxins type A and B.
    Authors: Desouza IA, Camargo EA, Mariano NS, Optiz-Neto JB, Resende JS, Mello GC, Costa SK, De Nucci G, Antunes E
    Eur. J. Pharmacol., 2009-04-16;613(1):128-34.
    Species: Rat
    Sample Types: BALF
  127. Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.
    Authors: Lim G, Wang S, Zhang Y, Tian Y, Mao J
    J. Clin. Invest., 2009-01-12;119(2):295-304.
    Species: Rat
    Sample Types: Cell Culture Supernates
  128. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.
    Authors: Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J
    Mol. Ther., 2008-06-10;16(8):1392-9.
    Species: Rat
    Sample Types: Tissue Homogenates
  129. Role of central beta-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge.
    Authors: Johnson JD, Cortez V, Kennedy SL, Foley TE, Hanson H, Fleshner M
    Brain Behav. Immun., 2008-05-12;22(7):1078-86.
    Species: Rat
    Sample Types: Plasma
  130. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
    Authors: Li PC, Chen WC, Chang LC, Lin SC
    Am. J. Physiol. Lung Cell Mol. Physiol., 2008-03-07;294(5):L912-20.
    Species: Rat
    Sample Types: BALF
  131. IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway.
    Authors: Temporin K, Tanaka H, Kuroda Y, Okada K, Yachi K, Moritomo H, Murase T, Yoshikawa H
    Biochem. Biophys. Res. Commun., 2007-11-08;365(2):375-80.
    Species: Rat
    Sample Types: Tissue Homogenates
  132. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.
    Authors: Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Butler K
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007-08-24;293(5):L1183-93.
    Species: Rat
    Sample Types: BALF
  133. Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol.
    Authors: de Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, Vargaftig BB, de Lima WT
    Am. J. Physiol., Cell Physiol., 2007-07-18;293(3):C1120-8.
    Species: Rat
    Sample Types: BALF
  134. Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model.
    Authors: Chang SL, Beltran JA, Swarup S
    J. Virol., 2007-06-06;81(16):8406-11.
    Species: Rat
    Sample Types: Serum
  135. Gene transfer to interfere with TNFalpha signaling in neuropathic pain.
    Authors: Hao S, Mata M, Glorioso JC, Fink DJ
    Gene Ther., 2007-04-19;14(13):1010-6.
    Species: Rat
    Sample Types: Tissue Homogenates
  136. Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat.
    Authors: Sheikh N, Dudas J, Ramadori G
    Lab. Invest., 2007-04-09;87(7):713-25.
    Species: Rat
    Sample Types: Serum
  137. Prothymosin alpha lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis.
    Authors: Shiau AL, Chen SY, Chang MY
    J. Immunol., 2007-04-01;178(7):4688-94.
    Species: Rat
    Sample Types: Tissue Homogenates
  138. Cell-based angiopoietin-1 gene therapy for acute lung injury.
    Authors: McCarter SD, Mei SH, Lai PF, Zhang QW, Parker CH, Suen RS, Hood RD, Zhao YD, Deng Y, Han RN, Dumont DJ, Stewart DJ
    Am. J. Respir. Crit. Care Med., 2007-02-22;175(10):1014-26.
    Species: Rat
    Sample Types: BALF
  139. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
    Authors: Schoeniger-Skinner DK, Ledeboer A, Frank MG, Milligan ED, Poole S, Martin D, Maier SF, Watkins LR
    Brain Behav. Immun., 2007-01-03;21(5):660-7.
    Species: Rat
    Sample Types: Tissue Homogenates
  140. The age-related attenuation in long-term potentiation is associated with microglial activation.
    Authors: Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA
    J. Neurochem., 2006-09-18;99(4):1263-72.
    Species: Rat
    Sample Types: Tissue Homogenates
  141. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
    Authors: Barkho BZ, Song H, Aimone JB
    Stem Cells Dev., 2006-06-01;15(3):407-21.
    Species: Rat
    Sample Types: Cell Culture Supernates
  142. Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat.
    Authors: Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B
    Crit. Care Med., 2005-10-01;33(10):2317-22.
    Species: Rat
    Sample Types: BALF
  143. Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation.
    Authors: Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J
    Arthritis Rheum., 2005-04-01;52(4):1319-24.
    Species: Rat
    Sample Types: Tissue Homogenates
  144. Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats.
    Authors: Robinson S, Petelenz K, Li Q, Cohen ML, Dechant A, Tabrizi N, Bucek M, Lust D, Miller RH
    Neurobiol. Dis., 2005-04-01;18(3):568-81.
    Species: Rat
    Sample Types: Amniotic Fluid
  145. Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses.
    Authors: O&amp;apos;Bryan MK
    Am. J. Physiol. Regul. Integr. Comp. Physiol., 2005-01-20;288(6):R1744-55.
    Species: Rat
    Sample Types: Tissue Homogenates
  146. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures.
    Authors: Labuzek K, Kowalski J, Gabryel B, Herman ZS
    Eur Neuropsychopharmacol, 2005-01-01;15(1):23-30.
    Species: Rat
    Sample Types: Cell Culture Supernates
  147. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
    Authors: Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR
    J. Neurosci., 2004-08-18;24(33):7353-65.
    Species: Rat
    Sample Types: Tissue Homogenates
  148. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
    Authors: Holguin A, O&amp;apos;Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR
    Pain, 2004-08-01;110(3):517-30.
    Species: Rat
    Sample Types: CSF
  149. Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma.
    Authors: Schubert T, Horch RE
    Ann. Surg., 2004-08-01;240(2):340-9.
    Species: Rat
    Sample Types: Tissue Homogenates
  150. Insulin attenuates the systemic inflammatory response in endotoxemic rats.
    Authors: Jeschke MG, Klein D, Bolder U, Einspanier R
    Endocrinology, 2004-06-10;145(9):4084-93.
    Species: Mouse
    Sample Types: Tissue Homogenates
  151. Gene transfer of tumor necrosis factor inhibitor improves the function of lung allografts.
    Authors: Tagawa T, Kozower BD, Kanaan SA, Daddi N, Muraoka M, Oka T, Ritter JH, Patterson GA
    J. Thorac. Cardiovasc. Surg., 2004-06-01;127(6):1558-63.
    Species: Rat
    Sample Types: Tissue Homogenates
  152. A method for measuring multiple cytokines from small samples.
    Authors: O&amp;apos;Connor KA
    Brain Behav. Immun., 2004-05-01;18(3):274-80.
    Species: Rat
    Sample Types: CSF
  153. Oral (gavage), in utero and post-natal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part II: effects on the immune system.
    Authors: Tryphonas H, Cooke G, Caldwell D, Bondy G, Parenteau M, Hayward S, Pulido O
    Food Chem. Toxicol., 2004-02-01;42(2):221-35.
    Species: Rat
    Sample Types: Serum
  154. Alveolar macrophage cytotoxicity for normal lung fibroblasts is mediated by nitric oxide release.
    Authors: Morgan DL, Shines CJ
    Toxicol In Vitro, 2004-02-01;18(1):139-46.
    Species: Rat
    Sample Types: Cell Culture Supernates
  155. Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats.
    Authors: Nedrebo T, Reed RK, Jonsson R, Berg A, Wiig H
    J. Physiol. (Lond.), 2004-01-14;556(0):193-202.
    Species: Rat
    Sample Types: Interstitial Fluid
  156. Differential expression of cytokine genes and inducible nitric oxide synthase induced by opacity phenotype variants of Streptococcus pneumoniae during acute otitis media in the rat.
    Authors: Long JP, Tong HH, Shannon PA, DeMaria TF
    Infect. Immun., 2003-10-01;71(10):5531-40.
    Species: Rat
    Sample Types: Tissue Secretion
  157. Recipient intramuscular cotransfection of naked plasmid transforming growth factor beta1 and interleukin 10 ameliorates lung graft ischemia-reperfusion injury.
    Authors: D&amp;apos;Ovidio F
    J. Thorac. Cardiovasc. Surg., 2002-08-01;124(2):259-69.
    Species: Rat
    Sample Types: BALF
  158. Role of IL-18 in acute lung inflammation.
    Authors: Jordan JA, Guo RF, Yun EC, Sarma V, Warner RL, Crouch LD, Senaldi G, Ulich TR, Ward PA
    J. Immunol., 2001-12-15;167(12):7060-8.
    Species: Rat
    Sample Types: BALF

FAQs

  1. Does this Quantikine ELISA Kit detect the pro form of the target protein?                        

    • This Quantikine ELISA kit is designed to detect both the natural and recombinant mature forms of the target protein.  The pro form of the target protein has not been evaluated in this assay.  To see the complete list of recombinant proteins tested for cross-reactivity or interference in this assay, please consult the "Specificity" section of the product insert. 

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Reviews for Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit

Average Rating: 4.8 (Based on 5 Reviews)

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Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit
By Shekhar Yeshwante on 08/11/2020
Sample Tested: Serum,Tissue Homogenates
Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit RLB00
Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit
By Anonymous on 03/13/2020
Sample Tested: Rat spinal cord

We tested IL-1β levels in homogenized rat spinal cord. The standard curve was excellent and the CV values were all very low. We have used kits from other companies and found RnD systems kits to be superior to all other companies. The kits from RnD systems result in much lower background levels and much lower CV levels, which really helps with consistency and repeatability. The image shows the standard curve and the green outlines the low CV values from a run containing homogenized rat spinal cord.

Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit RLB00
Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit
By Anonymous on 03/11/2019
Sample Tested: Brain (cortex) tissue,Brain (hippocampus),Brain (hypothalamus) tissue,Brain tissue

One of the best ELISA kits for IL-1B measurement. Used it with brain homogenates and results are very reproducible. Before this kit, i worked with IL-1B ELISA kits from 2 other vendors, however i could find lot of cross- reactivity. Based on my excellent experience with RnD's mice IL-1B ELISA kits i tried rat kits and they did not disappoint me. I definitely recommend this kit for all your IL-1B related research.

Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit RLB00
Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit
By Anonymous on 05/08/2018
Sample Tested: Heparin Plasma

Among best ELISAs I've worked with. Great consistency lot to lot, high sensitivity, easy to work with small amount of samples (50ul total, but samples can be diluted a number of times due to high sensitivity). Appropriate for concentration response curves. Linear standard curve for easy extrapolation of concentration values.

Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit RLB00
Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit, 2 Plate
By Anonymous on 02/26/2016
Sample Tested: Rat Brain Tissue Homogenate