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Recombinant Mouse CXCL12/SDF-1 alpha Protein

Catalog #: 460-SD
84 Citations 10 Reviews Datasheet / COA / SDS

Carrier Free

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460-SD-010/CF
460-SD-050/CF

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Catalog # Availability Size / Price Qty
460-SD-010
460-SD-050
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Recombinant Mouse CXCL12/SDF-1 alpha Protein Bioactivity
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Product Details
Citations (84)
FAQs
Reviews (10)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse CXCL12/SDF-1 alpha Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR4. The ED50 for this effect is 0.15-0.6 ng/mL. Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL). The ED50 for this effect is 3-9 ng/mL.
Source
E. coli-derived mouse CXCL12/SDF-1 alpha protein
Lys22-Lys89
Accession #
P40224
N-terminal Sequence
Analysis
Lys22
Predicted Molecular Mass
8 kDa

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460-SD (with carrier)

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COA
SDS

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460-SD/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

460-SD

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

460-SD/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse CXCL12/SDF-1 alpha Protein Bioactivity View Larger

Recombinant Mouse CXCL12/SDF-1 alpha (Catalog # 460-SD) chemoattracts the BaF3 mouse pro-B cells transfected with human CXCR4. The ED50 for this effect is 0.15-0.6 ng/mL.

SDS-PAGE Recombinant Mouse CXCL12/SDF-1 alpha Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse CXCL12/SDF-1 alpha was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: CXCL12/SDF-1 alpha

SDF-1 alpha and SDF-1 beta, members of the chemokine alpha subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line as cytokines that supported the proliferation of a stromal cell‑dependent pre-B-cell line, and were named Pre‑B‑Cell Growth Stimulating Factor (PBSF). SDF‑1 alpha  and SDF‑1 beta cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1 alpha and SDF‑1 beta are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy‑terminus of SDF-1 beta and absent from SDF‑1 alpha. SDF‑1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF‑1/PBSF acts via the chemokine receptor CXCR4 and has been shown to be a chemoattractant for T‑lymphocytes, monocytes, pro- and pre- B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 have been found to have impaired B‑lymphopoiesis, myelopoiesis, vascular development, cardiogenesis and abnormal neuronal cell migration and patterning in the central nervous system.

References
  1. Ma, Q. et al. (1998) Proc. Natl. Acad. Sci. USA 95:9448.
  2. Zou, Y.R. et al. (1998) Nature 393:595.
  3. Tachibana, K. et al. (1998) Nature 393:591.
Entrez Gene IDs
6387 (Human); 20315 (Mouse); 493806 (Feline)
Alternate Names
CXCL12 chemokine (C-X-C motif) ligand 12; CXCL12/SDF-1 alpha; IRH; PBSF; SCYB12; SDF1 alpha; SDF1; SDF1a; SDF1B; TLSF; TPAR1

Citations for Recombinant Mouse CXCL12/SDF-1 alpha Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

84 Citations: Showing 1 - 10
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  1. The Flavonoid Naringenin Alleviates Collagen-Induced Arthritis through Curbing the Migration and Polarization of CD4+ T Lymphocyte Driven by Regulating Mitochondrial Fission
    Authors: YP Jiang, JJ Wen, XX Zhao, YC Gao, X Ma, SY Song, Y Jin, TJ Shao, J Yu, CP Wen
    International Journal of Molecular Sciences, 2022-12-23;24(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. ICAP-1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice
    Authors: S Sevilla-Mo, P Fuentes, Y Rodríguez-, N Arellano-S, PW Krenn, SI de Val, S Montero-He, J García-Cec, V Burdiel-He, SR Gardeta, N Aguilera-M, C Barrio-Alo, G Crainiciuc, D Bouvard, A García-Par, AG Zapata, A Hidalgo, R Fässler, YR Carrasco, ML Toribio, J Teixidó
    European Journal of Immunology, 2022-05-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson's Disease
    Authors: V Penna, N Moriarty, Y Wang, KCL Law, CW Gantner, RJ Williams, DR Nisbet, CL Parish
    International Journal of Molecular Sciences, 2022-04-22;23(9):.
    Species: Mouse
    Sample Types: Protein
    Applications: Bioassay
  4. PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration
    Authors: W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg
    Nature Communications, 2022-04-21;13(1):2176.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. C?X?C receptor�7 agonist acts as a C?X?C motif chemokine ligand�12 inhibitor to ameliorate osteoclastogenesis and bone resorption
    Authors: AP Nugraha, H Kitaura, F Ohori, A Pramusita, S Ogawa, T Noguchi, A Marahleh, Y Nara, R Kinjo, I Mizoguchi
    Molecular Medicine Reports, 2022-01-11;25(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Glycogen synthase kinase 3 drives thymocyte egress by suppressing beta-catenin activation of Akt
    Authors: C Liu, L Ma, Y Wang, J Zhao, P Chen, X Chen, Y Wang, Y Hu, Y Liu, X Jia, Z Yang, X Yin, J Wu, S Wu, H Zheng, X Ma, X Sun, Y He, L Lin, Y Fu, K Liao, X Zhou, S Jiang, G Fu, J Tang, W Han, XL Chen, W Fan, Y Hong, J Han, X Huang, BA Li, N Xiao, C Xiao, G Fu, WH Liu
    Science Advances, 2021-10-08;7(41):eabg6262.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Ackr3-Venus knock-in mouse lights up brain vasculature
    Authors: AT Ehrlich, M Semache, P Couvineau, S Wojcik, H Kobayashi, M Thelen, F Gross, M Hogue, C Le Gouill, E Darcq, M Bouvier, BL Kieffer
    Molecular Brain, 2021-09-28;14(1):151.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect
    Authors: E Haring, FM Uhl, G Andrieux, M Proietti, A Bulashevsk, B Sauer, LM Braun, E de Vega Go, PR Esser, SF Martin, D Pfeifer, M Follo, A Schmitt-Gr, J Buescher, J Duyster, B Grimbacher, M Boerries, EL Pearce, R Zeiser, P Apostolova
    Haematologica, 2021-08-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. Plasma cell dynamics in the bone marrow niche
    Authors: Z Benet, Z Jing, DR Fooksman
    Cell Reports, 2021-02-09;34(6):108733.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
    Authors: K Spinler, J Bajaj, T Ito, B Zimdahl, M Hamilton, A Ahmadi, CS Koechlein, N Lytle, HY Kwon, F Anower-E-K, H Sun, A Blevins, J Weeks, M Kritzik, J Karlseder, MH Ginsberg, PW Park, JD Esko, T Reya
    Nat Commun, 2020-11-26;11(1):5998.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. IL18 signaling promotes homing of mature Tregs into the thymus
    Authors: C Peligero-C, T Givony, A Sebé-Pedró, J Dobeš, N Kadouri, S Nevo, F Roncato, R Alon, Y Goldfarb, J Abramson
    Elife, 2020-07-20;9(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Transient microglial absence assists postmigratory cortical neurons in proper differentiation
    Authors: Y Hattori, Y Naito, Y Tsugawa, S Nonaka, H Wake, T Nagasawa, A Kawaguchi, T Miyata
    Nat Commun, 2020-04-02;11(1):1631.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  13. beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
    Authors: S Giannini, MM Lee-Sundlo, L Rivadeneyr, CA Di Buduo, R Burns, JT Lau, H Falet, A Balduini, KM Hoffmeiste
    Nat Commun, 2020-01-17;11(1):356.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. CXCL12/CXCR4 signaling induced itch and pain sensation in a murine model of allergic contact dermatitis
    Authors: W Su, J Yu, Q Liu, L Ma, Y Huang
    Mol Pain, 2020-01-01;16(0):1744806920926.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
    Authors: S Giannini, MM Lee-Sundlo, L Rivadeneyr, CA Di Buduo, R Burns, JT Lau, H Falet, A Balduini, KM Hoffmeiste
    Nat Commun, 2020;11(1):356.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
    Authors: JM Bertho, D Kereselidz, L Manens, C Culeux, V Magneron, J Surette, M Blimkie, L Bertrand, H Wyatt, M Souidi, I Dublineau, N Priest, JR Jourdain
    Sci Rep, 2019-12-27;9(1):19919.
    Species: Mouse
    Sample Types: Plasma
    Applications: Multiplex Standard
  17. LncRNA Neat1 mediates miR-124-induced activation of Wnt/beta-catenin signaling in spinal cord neural progenitor cells
    Authors: Y Cui, Y Yin, Z Xiao, Y Zhao, B Chen, B Yang, B Xu, H Song, Y Zou, X Ma, J Dai
    Stem Cell Res Ther, 2019-12-18;10(1):400.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis
    Authors: M Mandal, MK Okoreeh, DE Kennedy, M Maienschei, J Ai, KC McLean, N Kaverina, M Veselits, I Aifantis, F Gounari, MR Clark
    Nat. Immunol., 2019-09-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms
    Authors: H Park, S Lad, K Boland, K Johnson, N Readio, G Jin, S Asfaha, KS Patterson, A Singh, X Yang, D Londono, A Singh, C Trempus, D Gordon, TC Wang, RJ Morris
    Nat Commun, 2018-12-13;9(1):5293.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
    Authors: L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello
    Cell Rep, 2018-12-11;25(11):3059-3073.e10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2
    Authors: B Wang, Y Guo, X Chen, C Zeng, Q Hu, W Yin, W Li, H Xie, B Zhang, X Huang, F Yu
    Int J Nanomedicine, 2018-11-12;13(0):7395-7408.
    Species: Human
    Sample Types: Nanoparticles
    Applications: Bioassay
  22. mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
    Authors: SK Martin, S Fitter, N El Khawank, RH Grose, CR Walkley, LE Purton, MA Ruegg, MN Hall, S Gronthos, ACW Zannettino
    Sci Rep, 2018-09-28;8(1):14501.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and ?1-integrin function
    Authors: V Andreani, S Ramamoorth, A Pandey, E Lupar, SL Nutt, T Lämmermann, R Grosschedl
    Proc. Natl. Acad. Sci. U.S.A., 2018-09-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses
    Authors: SJ Keppler, M Burbage, F Gasparrini, L Hartjes, S Aggarwal, MJ Massaad, RS Geha, A Bruckbauer, FD Batista
    Cell Rep, 2018-07-17;24(3):619-629.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction
    Authors: Y Duan, E Beli, S Li Calzi, JL Quigley, RC Miller, L Moldovan, D Feng, TE Salazar, S Hazra, J Al-Sabah, KV Chalam, T Le Phuong, M Meroueh, TA Markel, MC Murray, RJ Vyas, ME Boulton, P Parsons-Wi, GY Oudit, AG Obukhov, MB Grant
    Stem Cells, 2018-07-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. SDF-1 is an Autocrine Insulin-Desensitizing Factor in Adipocytes
    Authors: J Shin, A Fukuhara, T Onodera, S Kita, C Yokoyama, M Otsuki, I Shimomura
    Diabetes, 2018-03-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  27. Transmission of integrin ?7 transmembrane domain topology enables gut lymphoid tissue development
    Authors: H Sun, F Lagarrigue, AR Gingras, Z Fan, K Ley, MH Ginsberg
    J. Cell Biol., 2018-03-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models
    Authors: N Salazar, JC Carlson, K Huang, Y Zheng, C Oderup, J Gross, AD Jang, TM Burke, S Lewén, A Scholz, S Huang, L Nease, J Kosek, M Mittelbron, EC Butcher, H Tu, BA Zabel
    Mol. Ther., 2018-03-06;0(0):.
    Applications: Bioassay
  29. The Small Rho GTPase TC10 Modulates B Cell Immune Responses
    Authors: M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista
    J. Immunol., 2017-07-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis
    Authors: XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang
    Oncogene, 2017-05-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
    Authors: M Losada-Bar, A Umaña-Pére, S Cuervo-Esc, LR Berbert, R Porrozzi, FN Morgado, DA Mendes-da-, W Savino, M Sánchez-Gó, P Cuervo
    Sci Rep, 2017-04-11;7(0):45991.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
    Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
    Nat. Methods, 2017-04-10;14(5):531-538.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system
    Authors: K Choi, K Komurov, JS Fletcher, E Jousma, JA Cancelas, J Wu, N Ratner
    Sci Rep, 2017-03-03;7(0):43315.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Normal Thymocyte Egress, T Cell Trafficking, and CD4(+) T Cell Homeostasis Require Interactions between RGS Proteins and G?i2
    Authors: IY Hwang, C Park, K Harrison, JH Kehrl
    J. Immunol, 2017-02-24;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells
    Authors: Christina Schreck
    J. Exp. Med, 2016-12-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization
    Authors: Valentina Cecchinato
    J. Immunol, 2016-11-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo
    Authors: Simon X Liang
    Int. J. Cardiol., 2016-11-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. SDF-1?-induced dual pairs of E-selectin/ligand mediate endothelial progenitor cell homing to critical ischemia
    Sci Rep, 2016-10-07;6(0):34416.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  39. Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization
    Cell Rep, 2016-09-27;17(1):193-205.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens
    J Leukoc Biol, 2016-09-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
    Nat Commun, 2016-09-06;7(0):12719.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  42. Proplatelet formation is selectively inhibited by collagen type I via Syk-independent GPVI signaling
    J Cell Sci, 2016-08-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein
    Sci Rep, 2016-06-07;6(0):27054.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+ T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis
    Authors: S Velasquez, S Malik, SE Lutz, E Scemes, EA Eugenin
    J Immunol, 2016-04-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require ?4?1 Integrin To Migrate between the Peritoneum and Inflamed Skin
    Authors: SA Geherin, D Gómez, RA Glabman, G Ruthel, A Hamann, GF Debes
    J. Immunol, 2016-02-05;196(6):2514-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4.
    Authors: Chen Q, Zhang M, Li Y, Xu D, Wang Y, Song A, Zhu B, Huang Y, Zheng J
    Stem Cells, 2015-05-13;33(8):2574-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention.
    Authors: Wang W, Yu S, Zimmerman G, Wang Y, Myers J, Yu V, Huang D, Huang X, Shim J, Huang Y, Xin W, Qiao P, Yan M, Xin W, Scadden D, Stanley P, Lowe J, Huang A, Siebel C, Zhou L
    Stem Cells, 2015-05-13;33(7):2280-93.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK.
    Authors: Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M
    PLoS ONE, 2015-04-24;10(4):e0125340.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Milk fat globule-EGF factor VIII attenuates CNS injury by promoting neural stem cell proliferation and migration after cerebral ischemia.
    Authors: Cheyuo C, Aziz M, Yang W, Jacob A, Zhou M, Wang P
    PLoS ONE, 2015-04-13;10(4):e0122833.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. The role of some chemokines from the CXC subfamily in a mouse model of diabetic neuropathy.
    Authors: Zychowska M, Rojewska E, Pilat D, Mika J
    J Diabetes Res, 2015-02-19;2015(0):750182.
    Species: Mouse
    Sample Types: In Vivo
  51. CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia.
    Authors: Arieta Kuksin C, Gonzalez-Perez G, Minter L
    Blood, 2015-02-03;125(13):2087-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury.
    Authors: Wang Z, Wang Y, Wang Z, Gutkind J, Wang Z, Wang F, Lu J, Niu G, Teng G, Chen X
    Stem Cells, 2015-02-01;33(2):456-67.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. An essential role for RGS protein/Galphai2 interactions in B lymphocyte-directed cell migration and trafficking.
    Authors: Hwang I, Park C, Harrison K, Boularan C, Gales C, Kehrl J
    J Immunol, 2015-01-23;194(5):2128-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. GPCR-mediated PLCbetagamma/PKCbeta/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.
    Authors: Xu X, Gera N, Li H, Yun M, Zhang L, Wang Y, Wang Q, Jin T
    Mol Biol Cell, 2015-01-07;26(5):874-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease.
    Authors: Graham K, Zhang J, Lewen S, Burke T, Dang T, Zoudilova M, Sobel R, Butcher E, Zabel B
    PLoS ONE, 2014-12-01;9(12):e112925.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Control of lymphocyte egress from lymph nodes through beta2-adrenergic receptors.
    Authors: Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K
    J Exp Med, 2014-11-24;211(13):2583-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
    Authors: Beck T, Gomes A, Cyster J, Pereira J
    J Exp Med, 2014-11-17;211(13):2567-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.
    Authors: Scherz-Shouval R, Santagata S, Mendillo M, Sholl L, Ben-Aharon I, Beck A, Dias-Santagata D, Koeva M, Stemmer S, Whitesell L, Lindquist S
    Cell, 2014-07-31;158(3):564-78.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy.
    Authors: Menichella D, Abdelhak B, Ren D, Shum A, Frietag C, Miller R
    Mol Pain, 2014-06-25;10(0):42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. SDF-1 enhances wound healing of critical-sized calvarial defects beyond self-repair capacity.
    Authors: Jin, Qiming, Giannobile, William
    PLoS ONE, 2014-05-06;9(5):e97035.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  61. Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
    Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G
    Stem Cells, 2014-05-01;32(5):1347-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
    Authors: Geherin, Skye A, Wilson, R Paul, Jennrich, Silke, Debes, Gudrun F
    PLoS ONE, 2014-04-21;9(4):e95626.
    Species: Mouse, Ovine
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations.
    Authors: Januszyk M, Sorkin M, Glotzbach J, Vial I, Maan Z, Rennert R, Duscher D, Thangarajah H, Longaker M, Butte A, Gurtner G
    Diabetes, 2014-04-16;63(9):3047-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis.
    Authors: Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saitoh K, Yoshimura A, Matsuda T, Kanakura Y
    Eur J Immunol, 2014-04-15;44(6):1791-801.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches.
    Authors: Roy, Lopamudr, Sahraei, Mahnaz, Schettini, Jorge L, Gruber, Helen E, Besmer, Dahlia M, Mukherjee, Pinku
    BMC Cancer, 2014-03-27;14(0):225.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. alphaPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.
    Authors: Korthals M, Schilling K, Reichardt P, Mamula D, Schluter T, Steiner M, Langnase K, Thomas U, Gundelfinger E, Premont R, Tedford K, Fischer K
    J Immunol, 2014-03-03;192(7):3228-38.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. CCAAT/enhancer-binding protein beta expressed by bone marrow mesenchymal stromal cells regulates early B-cell lymphopoiesis.
    Authors: Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaor-Kondo A, Maekawa T
    Stem Cells, 2014-03-01;32(3):730-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein.
    Authors: Bosticardo, Marita, Musio, Silvia, Fontana, Elena, Angiari, Stefano, Draghici, Elena, Constantin, Gabriela, Poliani, Pietro L, Pedotti, Rosetta, Villa, Anna
    PLoS ONE, 2014-01-23;9(1):e86942.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Moesin controls clathrin-mediated S1PR1 internalization in T cells.
    Authors: Nomachi, Akira, Yoshinaga, Masanori, Liu, Jaron, Kanchanawong, Pakorn, Tohyama, Kiyoshi, Thumkeo, Dean, Watanabe, Takeshi, Narumiya, Shuh, Hirata, Takako
    PLoS ONE, 2013-12-16;8(12):e82590.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.
    Authors: Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K
    PLoS ONE, 2013-11-18;8(11):e80500.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach.
    Authors: Donnelly J, Chawla A, Houghton J, Zavros Y
    PLoS ONE, 2013-09-19;8(9):e75225.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
    Authors: Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R
    J Immunol, 2013-04-15;190(10):5329-36.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA (Capture)
  73. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth.
    Authors: Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J
    PLoS ONE, 2013-04-02;8(4):e60226.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Rgs13 constrains early B cell responses and limits germinal center sizes.
    Authors: Hwang I, Hwang K, Park C, Harrison K, Kehrl J
    PLoS ONE, 2013-03-22;8(3):e60139.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Early differentiated CD138(high) MHCII+ IgG+ plasma cells express CXCR3 and localize into inflamed kidneys of lupus mice.
    Authors: Lacotte S, Decossas M, Le Coz C, Brun S, Muller S, Dumortier H
    PLoS ONE, 2013-03-08;8(3):e58140.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Influence of hypoxia-inducible factor 1-alpha on dendritic cell differentiation and migration.
    Authors: Kohler T, Reizis B, Johnson RS, Weighardt H, Forster I
    Eur. J. Immunol., 2012-05-01;42(5):1226-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
    Authors: Ippagunta SK, Malireddi RK, Shaw PJ
    Nat. Immunol., 2011-09-04;12(10):1010-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control.
    Authors: Cha HR, Ko HJ, Kim ED
    J. Immunol., 2011-08-10;187(6):3044-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1.
    Authors: Kollmar O, Rupertus K, Scheuer C, Nickels RM, Haberl GC, Tilton B, Menger MD, Schilling MK
    Int. J. Cancer, 2010-03-15;126(6):1302-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.
    Authors: Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N
    J. Exp. Med., 2008-10-13;205(11):2643-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice.
    Authors: Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin QD
    Fertil. Steril., 2008-04-02;91(6):2687-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
    Authors: Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
    J. Immunol., 2007-06-15;178(12):8148-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy.
    Authors: Bhangoo SK, Ren D, Miller RJ, Chan DM, Ripsch MS, Weiss C, McGinnis C, White FA
    Brain Behav. Immun., 2007-02-09;21(5):581-91.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  84. The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
    Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
    Blood, 2004-09-09;105(1):31-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Anonymous on 11/17/2021
Application: In vitro bioactivity in cell culture
Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Anonymous on 04/23/2021
Application: In vitro bioactivity in cell culture
Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Anonymous on 01/29/2021
Application: In vitro bioactivity in cell culture
Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Anonymous on 11/04/2019
Application: Characterization prior to use in downstream assay.
Reason for Rating: MW matches theoretical by LC/MS.
Other Recombinant Mouse CXCL12/SDF-1 alpha Protein 460-SD
Recombinant Mouse CXCL12/SDF-1 alpha Protein
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Application: SDS-PAGE Control
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Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Jun Cai on 01/28/2019
Application: Cell migration/motility
Recombinant Mouse CXCL12/SDF-1 alpha Protein
By jayeeta giri on 01/28/2019
Application: Enzymatic activity in vitro
Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Anonymous on 12/16/2016
Application: Cell migration/motility
Cell migration/motility Recombinant Mouse CXCL12/SDF-1 alpha Protein 460-SD
Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Adam Guess on 08/03/2016
Application: Cell migration/motility
Cell migration/motility Recombinant Mouse CXCL12/SDF-1 alpha Protein 460-SD
Recombinant Mouse CXCL12/SDF-1 alpha Protein
By Anonymous on 05/17/2016
Application: In vitro bioactivity in cell culture