Recombinant Mouse IL-22 Protein Summary
Product Specifications
Leu34-Val179, with an N-terminal Met
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
582-ML
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Reconstitution | Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
582-ML/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: IL-22
Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human IL-22 and IL-10, respectively. The mouse IL-22 gene is localized to chromosome 10. Although it exists as a single copy gene in many mouse strains, the IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta, share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.
- Dumoutier, L. et al. (2000) J. Immunol. 164:1814.
- Xie, M-H. et al. (2000) J. Biol. Chem. 275:31335.
- Dumoutier, L. et al. (2000) PNAS 97:10144.
- Kotenko, S.V. et al. (2001) J. Biol. Chem. 276:2725.
Citations for Recombinant Mouse IL-22 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Dihydromyricetin Protects Intestinal Barrier Integrity by Promoting IL-22 Expression in ILC3s through the AMPK/SIRT3/STAT3 Signaling Pathway
Authors: J Zhou, J Yue, Y Yao, P Hou, T Zhang, Q Zhang, L Yi, M Mi
Nutrients, 2023-01-10;15(2):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response
Authors: F Abdallah, E Henriet, A Suet, A Arar, R Clemençon, JM Malinge, G Lecellier, P Baril, C Pichon
Cells, 2021-09-26;10(10):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Phospholipase C epsilon mediates cytokine cascade induced by acute disruption of epidermal permeability barrier in mice
Authors: J Zhang, J Wu, M Sun, S Zhang, J Huang, M Man, L Hu
Biochemistry and Biophysics Reports, 2020-12-09;24(0):100869.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists
Authors: J Chen, CA Haller, FE Jernigan, SK Koerner, DJ Wong, Y Wang, JE Cheong, R Kosaraju, J Kwan, DD Park, B Thomas, S Bhasin, RC De La Rosa, AM Premji, L Liu, E Park, AC Moss, A Emili, M Bhasin, L Sun, EL Chaikof
Sci Adv, 2020-01-15;6(3):eaay8230.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
T cell deletion of MyD88 connects IL-17 and IkBz to RAS oncogenesis
Authors: C Cataisson, R Salcedo, AM Michalowsk, M Klosterman, S Naik, L Li, MJ Pan, A Sweet, JQ Chen, LG Kostecka, M Karwan, L Smith, RM Dai, CA Stewart, L Lyakh, WT Hsieh, A Khan, H Yang, M Lee, G Trinchieri, SH Yuspa
Mol. Cancer Res., 2019-06-04;0(0):.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
Authors: H Katsura, Y Kobayashi, PR Tata, BLM Hogan
Stem Cell Reports, 2019-03-28;0(0):.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Protection against Staphylococcus aureus Colonization and Infection by B- and T-Cell-Mediated Mechanisms
Authors: F Zhang, O Ledue, M Jun, C Goulart, R Malley, YJ Lu
MBio, 2018-10-16;9(5):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling
Authors: JM Zha, HS Li, Q Lin, WT Kuo, ZH Jiang, PY Tsai, N Ding, J Wu, SF Xu, YT Wang, J Pan, XM Zhou, K Chen, M Tao, MA Odenwald, A Tamura, S Tsukita, JR Turner, WQ He
Cell Mol Gastroenterol Hepatol, 2018-09-18;7(2):255-274.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function
Authors: J Wu, J Gu, S Zhou, H Lu, Y Lu, L Lu, X Wang
J Immunol Res, 2018-08-07;2018(0):1605341.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model
Authors: B Zwarycz, AD Gracz, KR Rivera, IA Williamson, LA Samsa, J Starmer, MA Daniele, L Salter-Cid, Q Zhao, ST Magness
Cell Mol Gastroenterol Hepatol, 2018-07-04;7(1):1-17.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Administration of RANKL boosts thymic regeneration upon bone marrow transplantation
Authors: N Lopes, H Vachon, J Marie, M Irla
EMBO Mol Med, 2017-06-01;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22
Authors: YH Ni, LJ Huo, TT Li
World J. Gastroenterol., 2017-03-21;23(11):2002-2011.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection
Authors: P Treerat, O Prince, A Cruz-Lagun, M Muñoz-Torr, MA Salazar-Le, M Selman, B Fallert-Ju, TA Reinhardt, JF Alcorn, D Kaushal, J Zuñiga, J Rangel-Mor, JK Kolls, SA Khader
Mucosal Immunol, 2017-03-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection
Authors: J Gray, K Oehrle, G Worthen, T Alenghat, J Whitsett, H Deshmukh
Sci Transl Med, 2017-02-08;9(376):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection
Sci Rep, 2016-09-21;6(0):32927.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Goblet Cell Derived RELM-beta Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation.
Authors: Bergstrom K, Morampudi V, Chan J, Bhinder G, Lau J, Yang H, Ma C, Huang T, Ryz N, Sham H, Zarepour M, Zaph C, Artis D, Nair M, Vallance B
PLoS Pathog, 2015-08-18;11(8):e1005108.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection.
Authors: Munoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kuhl A, Wang X, Manzanillo P, Li Y, Rutz S, Zheng Y, Diehl L, Kayagaki N, van Lookeren-Campagne M, Liesenfeld O, Heimesaat M, Ouyang W
Immunity, 2015-02-10;42(2):321-31.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes.
Authors: Wang, Xiaoting, Ota, Naruhisa, Manzanillo, Paolo, Kates, Lance, Zavala-Solorio, Jose, Eidenschenk, Celine, Zhang, Juan, Lesch, Justin, Lee, Wyne P, Ross, Jed, Diehl, Lauri, van Bruggen, Nicholas, Kolumam, Ganesh, Ouyang, Wenjun
Nature, 2014-08-06;514(7521):237-41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M.
Authors: Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F
PLoS ONE, 2014-07-10;9(7):e101937.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-gamma.
Authors: Farin H, Karthaus W, Kujala P, Rakhshandehroo M, Schwank G, Vries R, Kalkhoven E, Nieuwenhuis E, Clevers H
J Exp Med, 2014-06-30;211(7):1393-405.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Candida albicans airway exposure primes the lung innate immune response against Pseudomonas aeruginosa infection through innate lymphoid cell recruitment and interleukin-22-associated mucosal response.
Authors: Mear J, Gosset P, Kipnis E, Faure E, Dessein R, Jawhara S, Fradin C, Faure K, Poulain D, Sendid B, Guery B
Infect Immun, 2013-10-28;82(1):306-15.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.
Authors: Turner, Jan-Eric, Stockinger, Brigitta, Helmby, Helena
PLoS Pathog, 2013-10-10;9(10):e1003698.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950.
Authors: Natividad J, Hayes C, Motta J, Jury J, Galipeau H, Philip V, Garcia-Rodenas C, Kiyama H, Bercik P, Verdu E
Appl Environ Microbiol, 2013-10-04;79(24):7745-54.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing.
Authors: Li Z, Burns AR, Miller SB, Smith CW
FASEB J., 2011-04-25;25(8):2659-68.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
J. Virol., 2010-09-29;84(24):12703-12.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.
Authors: Blumberg H, Dinh H, Dean C, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE
J. Immunol., 2010-09-10;185(7):4354-62.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-22 defines a novel immune pathway of antifungal resistance.
Authors: De Luca A, Zelante T, D'Angelo C
Mucosal Immunol, 2010-05-05;3(4):361-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis.
Authors: Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F
J. Immunol., 2010-03-24;184(0):5263-70.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.
Authors: Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK
Nat. Med., 2008-02-10;14(3):275-81.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
J. Immunol., 2007-05-01;178(9):5973-81.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2006-05-01;36(5):1309-23.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-22 increases the innate immunity of tissues.
Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
Immunity, 2004-08-01;21(2):241-54.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo
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