Ro 20-1724

Catalog # Availability Size / Price Qty
0415/50
Ro 20-1724 | CAS No. 29925-17-5 | Phosphodiesterase Inhibitors
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Description: PDE4 inhibitor

Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone

Purity: ≥99%

Product Details
Citations (3)
Reviews

Biological Activity

Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM).

Technical Data

M.Wt:
278.35
Formula:
C15H22N2O3
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
29925-17-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
    Nature, 2012;492(7427):123-7.
  3. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
    Ahluwalia and Nicholson et al.
    TiPS, 1991;12:19
  4. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
    Soderling et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:8991
  5. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle.
    Reeves et al.
    Biochem.J., 1987;241:535

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Citations for Ro 20-1724

The citations listed below are publications that use Tocris products. Selected citations for Ro 20-1724 include:

3 Citations: Showing 1 - 3

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