Ro 60-0175 fumarate
Chemical Name: (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate
Purity: ≥98%
Biological Activity
Ro 60-0175 fumarate is a potent, selective 5-HT2 receptor agonist; shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine2C receptor agonist.
Damjanoska et al.
J.Pharmacol.Exp.Ther., 2003;304:1209 -
Effects of Ro 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety.
Kennett et al.
Eur.J.Pharmacol., 2000;387:197 -
5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.
Martin et al.
J.Pharmacol.Exp.Ther., 1998;286:913 -
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
J.Med.Chem., 2013;56:1211
Product Datasheets
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Citations for Ro 60-0175 fumarate
The citations listed below are publications that use Tocris products. Selected citations for Ro 60-0175 fumarate include:
10 Citations: Showing 1 - 10
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Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
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Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
Authors: Kasper Et al.
J Neurophysiol 2015;69:78
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5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence.
Authors: Martin Et al.
Synapse 2015;18
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Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress.
Authors: Martin Et al.
J Neurochem 2014;131:566
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Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization.
Authors: Craige and Unterwald
Behav Brain Res 2013;238:206
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Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys.
Authors: Manvich Et al.
J Pharmacol Exp Ther 2012;341:424
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Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis.
Authors: Yu and Yamaguchi
J Biol Chem 2010;103:648
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5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
Authors: Yu and Yamaguchi
J Neurophysiol 2009;102:752
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Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.
Authors: Kawahara Et al.
J Neurosci 2008;28:12834
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Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Authors: Mbaki
Br J Pharmacol 2008;155:343
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