Ro 67-7476
Chemical Name: (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
Purity: ≥99%
Biological Activity
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu1 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat et al.
Mol.Pharmacol., 2006;70:616 -
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
Knoflach et al.
Proc.Natl.Acad.Sci.USA, 2001;98:13402
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Citations for Ro 67-7476
The citations listed below are publications that use Tocris products. Selected citations for Ro 67-7476 include:
2 Citations: Showing 1 - 2
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BACE1 controls synaptic function through modulating release of synaptic vesicles.
Authors: Wanxia Et al.
Mol Psychiatry 2021;26:6394-6410
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SHANK3 controls maturation of social reward circuits in the VTA.
Authors: Bariselli Et al.
Nat Neurosci 2016;19:926
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