Ro 6842262
Chemical Name: 1-[4'-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1'-biphenyl]-4-yl]cyclopropanecarboxylic acid
Purity: ≥98%
Biological Activity
Ro 6842262 is a potent LPA1 antagonist (IC50 = 25 nM). Exhibits >1,200-fold selectivity for LPA1 over LPA3. Attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro. Also reduces plasma histamine levels in mouse LPA-challenge model. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts.
Qian et al.
J.Med.Chem., 2012;55:7920
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for Ro 6842262
The citations listed below are publications that use Tocris products. Selected citations for Ro 6842262 include:
1 Citation: Showing 1 - 1
-
The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis.
Authors: Robert Et al.
Theranostics 2023;13:1921-1948
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Ro 6842262
There are currently no reviews for this product. Be the first to review Ro 6842262 and earn rewards!
Have you used Ro 6842262?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
