Rosiglitazone
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Description: Potent and selective PPARγ agonist; antidiabetic agent
Alternative Names: BRL 49653
Chemical Name: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥98%
Biological Activity
Rosiglitazone is a potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.Technical Data
M.Wt:
357.43
Formula:
C18H19N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
122320-73-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium
KP Ganti, A Mukherji, M Surjit, M Li, P Chambon
Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):. -
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
Lehmann et al.
J.Biol.Chem., 1995;270:12953 -
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
Willson et al.
J.Med.Chem., 1996;39:665 -
Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity.
Santos et al.
Nat.Commun., 2019;10:4407
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Citations for Rosiglitazone
The citations listed below are publications that use Tocris products. Selected citations for Rosiglitazone include:
15 Citations: Showing 1 - 10
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Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy.
Authors: Elisabetta Et al.
EMBO Mol Med 2023;15:e16225
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Ketogenic diet prevents paclitaxel-induced neuropathic nociception through activation of PPARγ signalling pathway and inhibition of neuroinflammation in rat dorsal root ganglion.
Authors: Chang Et al.
Eur J Neurosci 2021;54:5341-5356
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Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome.
Authors: Vincenzo Et al.
Molecules 2021;27
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Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists.
Authors: Vincenzo Et al.
Cells 2021;10
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Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State.
Authors: Liang Et al.
Cell Stem Cell 2020;27:784-797.e11
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Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study.
Authors: Luciano Et al.
Molecules 2020;25
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Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets
Authors: Fellous Et al.
Biochemical Pharmacology 2020;175
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Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.
Authors: Smith Et al.
Psychopharmacology (Berl) 2019;
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A structural mechanism for directing corepressor-selective inverse agonism of PPARγ.
Authors: Brust Et al.
Nat Commun 2018;9:4687
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Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.
Authors: Vitale Et al.
Mar Drugs 2018;16
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High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells.
Authors: Mark Et al.
Front Pharmacol 2017;8:772
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FOXA1, GATA3 and PPARγ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines.
Authors: Warrick Et al.
Sci Rep 2016;6:38531
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Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.
Authors: Matsa Et al.
Cell Stem Cell. 2016;19:311
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Studies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene.
Authors: Ahlem Et al.
Int J Clin Exp Med 2011;4:119
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Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution.
Authors: Yun-Hee Et al.
J Immunol 2009;183:3040-52
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