RQ 00203078

Catalog # Availability Size / Price Qty
5388/10
5388/50
RQ 00203078 | CAS No. 1254205-52-1 | TRPM Blockers
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Description: Potent and selective TRPM8 antagonist; orally active

Chemical Name: 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

RQ 00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin-induced wet dog shakes in rats. Orally active.

Technical Data

M.Wt:
554.85
Formula:
C21H13ClF6N2O5S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1254205-52-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for RQ 00203078

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2 Citations: Showing 1 - 2

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