RS 23597-190 hydrochloride

Catalog #: 0728
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0728/10
0728/50

RS 23597-190 hydrochloride | CAS No. 149719-06-2 | 5-HT4 Receptor Antagonists

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Description: 5-HT4 antagonist

Chemical Name: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride

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Product Details

Citations (5)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT₄ receptors.

Technical Data

M.Wt:

363.28

Formula:

C₁₆H₂₃ClN₂O₃.HCl

Solubility:

Soluble to 100 mM in water

Storage:

Store at RT

CAS No:

149719-06-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of Roche Bioscience

Background References

RS 23597-190: a potent and selective 5-HT₄ receptor antagonist.
Eglen et al.
Br.J.Pharmacol., 1993;110:119
Central 5-HT₄ receptors.
Eglen et al.
TiPS, 1995;16:391

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for RS 23597-190 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:

5 Citations: Showing 1 - 5

Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
Authors: Du Et al.
FASEB J 2015;29:2194
Neuregulin-1 enhances depolarization-induced GABA release.
Authors: Woo Et al.
Neuron 2007;54:599
5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala.
Authors: Huang and Kandel
J Pharmacol Exp Ther 2007;27:3111
Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats.
Authors: Kato Et al.
J Neurosci 2006;26:1787
Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.
Authors: Xiang Et al.
J Neurophysiol 2005;93:1145

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