Home / GABA Transporter Inhibitors / (S)-SNAP 5114

(S)-SNAP 5114

Catalog #: 1561
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1561/10
1561/50
(S)-SNAP 5114 | CAS No. 157604-55-2 | GABA Transporter Inhibitors
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Description: GABA uptake inhibitor

Chemical Name: 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.

Technical Data

M.Wt:
505.61
Formula:
C30H35NO6
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
157604-55-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (S)-SNAP 5114

The citations listed below are publications that use Tocris products. Selected citations for (S)-SNAP 5114 include:

5 Citations: Showing 1 - 5

  1. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Physiol  2016;36:607
  2. Recurrent seizure-like events are associated with coupled astroglial synchronization.
    Authors: Kékesi Et al.
    J Neurosci  2015;9:215
  3. A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus.
    Authors: Kersanté Et al.
    J Neurophysiol  2013;591:2429
  4. Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.
    Authors: Herd Et al.
    J Neurosci  2013;33:14850
  5. GAT-3 transporters regulate inhibition in the neocortex.
    Authors: Kinney
    Mol Pain  2005;94:4533

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