SAHM1

Catalog #: 6477 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6477/1

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Description: Notch pathway inhibitor; prevents Notch complex assembly

Purity: ≥95%

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Biological Activity

SAHM1 is a notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Technical Data

M.Wt:

2196.58

Formula:

C₉₄H₁₆₂N₃₆O₂₃S

Sequence:

AERLRRRIXLCRXHHST

(Modifications: Ala-1 = N-terminal Ac & β-Ala, X = (S)-2-(4-pentenyl)alanine, X-9 and X-13 stapled together with a double bond)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

2050906-89-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Notch signaling promotes osteoclast maturation and resorptive activity.
Ashley et al.
J Cell Biochem, 2015;116:2598
Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields.
Bagheri et al.
J.Tissue Eng.Regen.Med., 2018;12:304
The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma.
KleinJan et al.
J.Allergy Clin.Immunol., 2018;142:76

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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