Saquinavir mesylate

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.
   Krausslich et al.
   J.Virol., 1992;66:567
2. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
   Tucker et al.
   J.Med.Chem., 1992;35:2525
3. Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease.
   Kaldor et al.
   Bioorg.Med.Chem.Lett., 1995;5:721
4. Rational design of peptide-based HIV proteinase inhibitors.
   Roberts et al.
   Science, 1990;248:358

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