SB 258719 hydrochloride

Catalog #: 2726
3 Citations Datasheet / COA / SDS

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SB 258719 hydrochloride | CAS No. 1217674-10-6 | 5-HT7 Receptor Antagonists

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Description: Selective 5-HT7 antagonist

Chemical Name: 3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride

Purity: ≥99%

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Product Details

Citations (3)

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Biological Activity

SB 258719 hydrochloride is a selective 5-HT₇ receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.

Technical Data

M.Wt:

374.97

Formula:

C₁₈H₃₀N₂O₂S.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

1217674-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from GlaxoSmithKline

Background References

(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide: the first selective 5-HT₇ receptor antagonist.
Forbes et al.
J.Med.Chem., 1998;41:655
Functional characterisation of the human cloned 5-HT₇ receptor (long form); antagonist profile of SB-258719.
Thomas et al.
Br.J.Pharmacol., 1998;124:1300
The hypothermic effect of 5-CT in mice is mediated through the 5-HT₇receptor.
Guscott et al.
Neuropharmacology, 2003;44:1031

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SB 258719 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 258719 hydrochloride include:

3 Citations: Showing 1 - 3

Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.
Authors: Dom?nguez-Soto
Sci Rep 2017;7(1):14761
Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system.
Authors: Zhao Et al.
Front Synaptic Neurosci 2015;5:9043
Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
Authors: Johnson Et al.
Neuroscience 2011;192:372

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