SCH 336
Chemical Name: N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide
Purity: ≥98%
Biological Activity
SCH 336 is a highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases Forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo.
Lunn et al.
J.Pharmacol.Exp.Ther., 2006;316:780
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Citation for SCH 336
The citations listed below are publications that use Tocris products. Selected citations for SCH 336 include:
1 Citation: Showing 1 - 1
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Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption.
Authors: Dos-Santos-Pereira Et al.
Glia 2020;68:561
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