Simple Plex Human IL-22 Cartridge
Simple Plex Human IL-22 Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Product Summary
Precision
Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma
Intra-Assay Precision | Inter-Assay Precision | |||
---|---|---|---|---|
Sample | 1 | 2 | 1 | 2 |
n | 16 | 16 | 56 | 56 |
Mean (pg/mL) | 426 | 21967 | 449 | 22902 |
Standard Deviation | 29.1 | 847 | 42.2 | 1579 |
CV% | 6.8 | 3.9 | 9.4 | 6.9 |
Recovery
Recovery at three different spiked concentrations within the range of the assay was evaluated.
Sample Type | Average % Recovery | Range % |
---|---|---|
EDTA Plasma (n=4) | 96 | 89-99 |
Heparin Plasma (n=4) | 91 | 87-101 |
Serum (n=4) | 98 | 94-103 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: IL-22
IL-22 (Interleukin-22) is a cytokine that induces the production of reactive oxygen species, IL-6, IL-10, and TNF-alpha as well as neutrophil infiltration during inflammation. It also supports the integrity of epithelial barriers and induces epithelial cell proliferation during wound healing. IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. IL-10 R beta is a shared component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29. IL-22 additionally binds to IL-22BP which blocks the interaction of IL-22 with IL-22 R.
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