Simple Plex Human Serpin E1/PAI-1 Cartridge

Simple Plex Human Serpin E1/PAI-1 Cartridge Summary

*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.

Product Summary

Recovery

Linearity

Product Datasheets

Preparation and Storage

Background: Serpin E1/PAI-1

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Related Research Areas

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• Complement Pathway
• DNA Damage and Repair
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• Mesenchymal Cells and EMT
• Plasmin/Plasminogen and Kallikrein/Kinin Systems
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• Serine Proteases and Regulators