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SKF 86466 hydrochloride

Catalog #: 3866
1 Citation Datasheet / COA / SDS
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3866/10
3866/50
SKF 86466 hydrochloride | CAS No. 86129-54-6 | Adrenergic alpha-2 Receptor Antagonists
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Description: Potent and selective α2 antagonist

Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Technical Data

M.Wt:
232.15
Formula:
C11H14ClN.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
86129-54-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for SKF 86466 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SKF 86466 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
    Authors: Zeltner Et al.
    Nat Med  2016;22:1421

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