Home / GABA Transporter Inhibitors / SKF 89976A hydrochloride

SKF 89976A hydrochloride

Catalog #: 1081
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1081/10
1081/50
SKF 89976A hydrochloride | CAS No. 85375-15-1 | GABA Transporter Inhibitors
1 Image
Description: Potent GAT-1 inhibitor; brain penetrant

Chemical Name: 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo.

Technical Data

M.Wt:
371.91
Formula:
C22H25NO2.HCl
Solubility:
Soluble to 100 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
85375-15-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

Background References

  1. Orally active and potent inhibitors of γ-aminobutyric acid.
    Ali et al.
    J.Med.Chem., 1985;28:653
  2. Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
    Krause and Schwarz
    Mol.Pharmacol., 2005;68:1728
  3. On the bioactive conformation of the GABA uptake inhibitor SK&F 89976-A.
    Murali Dha
    Bioorg.Med.Chem.Lett., 1996;6:1535

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for SKF 89976A hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SKF 89976A hydrochloride include:

1 Citation: Showing 1 - 1

  1. Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
    Authors: Sousa Et al.
    Neuropsychopharmacology  2011;36:472

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SKF 89976A hydrochloride

There are currently no reviews for this product. Be the first to review SKF 89976A hydrochloride and earn rewards!

Have you used SKF 89976A hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.