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SKF 97541

Catalog #: 0379
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0379/10
0379/50
SKF 97541 | CAS No. 127729-35-5 | GABA-B Receptor Agonists
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Description: Highly potent GABAB agonist; also GABAA-ρ antagonist
Alternative Names: CGP 35024

Chemical Name: 3-Aminopropyl(methyl)phosphinic acid

Product Details
Citations (8)
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Biological Activity

SKF 97541 is a potent GABAB agonist (EC50 = 50 nM). SKF 97541 depresses striatal synaptic potentials and hyperpolarizes nigral neurons (EC50 values = 92 nM and 150 nM, respectively). SKF 97541 shows antidepressant effects in animal models and is also a GABAA-ρ antagonist.

Technical Data

M.Wt:
137.12
Formula:
C4H12NO2P
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
127729-35-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SKF 97541

The citations listed below are publications that use Tocris products. Selected citations for SKF 97541 include:

8 Citations: Showing 1 - 8

  1. Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila.
    Authors: Martelli and Fiala
    Elife  2019;8
  2. Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive.
    Authors: Ki and Lim
    Elife  2019;8
  3. FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor.
    Authors: Lecat-Guillet
    Cell Chem Biol  2017;24(3):360
  4. Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.
    Authors: Ignell Et al.
    Br J Pharmacol  2009;106:13070
  5. A presynaptic gain control mechanism fine-tunes olfactory behavior.
    Authors: Root Et al.
    Neuron  2008;59:311
  6. Differential regulation of mor. antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice.
    Authors: Chen Et al.
    Mol Pain  2008;4:41
  7. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol  2004;142:1038
  8. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    Mol Pain  2000;131:1050

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