SN 38
Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
Purity: ≥98%
Biological Activity
SN 38 is an active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
Kawato et al.
Cancer Res., 1991;51:4187 -
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Gao et al.
Bioorg.Med.Chem.Lett., 2005;15:3233 -
Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-Secr.g bulky tumors.
Koizumi et al.
Cancer Res., 2006;66:10048
Product Datasheets
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Citations for SN 38
The citations listed below are publications that use Tocris products. Selected citations for SN 38 include:
10 Citations: Showing 1 - 10
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Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer.
Authors: Prill Et al.
Oncotarget 2019;10:4731
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Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment.
Authors: Guillon Et al.
Cell Death Dis 2019;10:199
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Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells.
Authors: Wolff Et al.
Oncotarget 2018;9:25796
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Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy.
Authors: Duff Et al.
Cell Death Dis 2018;9:199
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Akt inhibition improves irino. treatment and prevents cell emergence by switching the senescence response to apoptosis.
Authors: Vétillard Et al.
Exp Neurol 2015;6:43342
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Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1.
Authors: Jonchère Et al.
Oncotarget 2015;6:409
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Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
Authors: Kathawala Et al.
Int J Oncol 2014;44:1634
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Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent.
Authors: Chen Et al.
Chembiochem 2014;15:2729
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Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.
Authors: Ni Et al.
Biochemistry 2011;50:8057
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Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport.
Authors: Ni Et al.
Am J Physiol Cell Physiol 2010;299:C1100
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