SNC 80
Chemical Name: (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Purity: ≥98%
Biological Activity
SNC 80 is a highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist.
Bilsky et al.
J.Pharmacol.Exp.Ther., 1995;273:359 -
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
Knapp et al.
J.Pharmacol.Exp.Ther., 1996;277:1284 -
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid
Calderon et al.
J.Med.Chem., 1994;37:2125
Product Datasheets
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Citations for SNC 80
The citations listed below are publications that use Tocris products. Selected citations for SNC 80 include:
18 Citations: Showing 1 - 10
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Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice.
Authors: Robins Et al.
Front Psychiatry 2018;9:112
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Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
Authors: Wang Et al.
Neuron 2018;98:90
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Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.
Authors: Ye
Neuroscience 2017;363:50
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A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
Authors: Levoye Et al.
Brain Struct Funct 2015;6:167
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A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.
Authors: Erbs Et al.
J Neurosci 2015;220:677
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Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
Authors: Schuster Et al.
Transl Oncol 2015;172:642
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Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking.
Authors: Ong Et al.
Front Endocrinol (Lausanne) 2015;172:615
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The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.
Authors: Neumann Et al.
J Invest Dermatol 2015;135:471
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δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.
Authors: Pradhan Et al.
Br J Pharmacol 2014;171:2375
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Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism.
Authors: Milan-Lobo Et al.
PLoS One 2013;8:e58362
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Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
Authors: Burbassi Et al.
Eur J Neurosci 2010;32:1278
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The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects.
Authors: Butelman Et al.
Psychopharmacology (Berl) 2010;210:253
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Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Authors: Pacheco Et al.
Br J Pharmacol 2009;158:225
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N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface.
Authors: Markkanen and Petäjä-Repo
J Biol Chem 2008;283:29086
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The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Authors: Pacheco Et al.
Br J Pharmacol 2008;154:1143
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Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.
Authors: Scherrer Et al.
Proc Natl Acad Sci U S A 2006;103:9691
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Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists.
Authors: Sluka Et al.
J Pharmacol Exp Ther 2002;302:1146
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Heterodimerization of μ and δ opioid receptors: A role in opiate synergy.
Authors: Gomes Et al.
Br J Pharmacol 2000;20:RC110
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