SP 600125

Type I and Type III IF.s Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.
Authors: Pervolaraki Et al.
Front Immunol  2017;8:459

Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells.
Authors: Sidhar and Giri
Sci Rep  2017;7:41420

TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells.
Authors: Wu
Arch Biochem Biophys  2017;622:26

TNFα induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling.
Authors: Zhou
Int Immunopharmacol  2017;54:296

Focal Adhesion Kinase Promotes the Progression of Aortic Aneurysm by Modulating Macrophage Behavior.
Authors: Harada Et al.
Arterioscler Thromb Vasc Biol  2017;37:156

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.
Authors: Martínez-Sánchez Et al.
Cell Metab  2017;26:212

Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Authors: Yang Et al.
Cell  2017;169:243

Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
Authors: Han
Brain Res  2017;1663:132

WNT5a is required for normal ovarian follicle development and antagonizes g.tropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
Authors: Abedini Et al.
FASEB J  2016;30:1534

Estrogen receptor β controls MMP-19 expression in mouse ovaries during ovulation.
Authors: Nalvarte Et al.
Reproduction  2016;151:253

Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells.
Authors: Chang Et al.
PLoS One  2016;11:e0165715

18α-glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis.
Authors: Rahman Et al.
Biochemical Pharmacology  2016;117:97

Effects of jnk inhibitor on inflammation and fibrosis in the ovary tissue of a rat model of polycystic ovary syndrome.
Authors: Bulut Et al.
Exp Hematol Oncol  2015;8:8774

Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment.
Authors: Liu Et al.
Int J Mol Sci  2015;5:79

Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated Ins secretion from human pancreatic islets.
Authors: Edén Et al.
Diabetologia  2015;58:2563

Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma.
Authors: Koerber Et al.
Nat Commun  2015;4:21

Free fatty acids shift Ins-induced hepatocyte proliferation towards CD95-dependent apoptosis.
Authors: Sommerfeld Et al.
J Biomed Sci  2015;290:4398

Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway.
Authors: Chen Et al.
Int J Clin Exp Pathol  2015;2015:414250

Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
Authors: Yang Et al.
PLoS One  2015;2015:270428

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.
Authors: Karmakar Et al.
Nat Commun  2015;194:1763

Inhibitory effect of STAT on inflammation-related pathways in human abdominal aortic aneurysm tissue.
Authors: Yoshimura Et al.
Biomed Res Int  2015;16:11213

Activation of transcription factor AP-1 in response to thermal injury in rat small intestine and IEC-6 cells.
Authors: Zhang Et al.
BMC Gastroenterol  2015;15:83

The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Authors: Smith Et al.
J Biol Chem  2015;10:e0136546

Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor.
Authors: Yuri Et al.
PLoS One  2015;10:e0129242

Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice.
Authors: Zhang Et al.
PLoS One  2014;9:e97824

Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
Authors: Yu Et al.
PLoS One  2014;9:e112989

Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.
Authors: Gonsalves Et al.
Am J Hematol  2014;89:273

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
Authors: Alpár Et al.
Steroids  2014;5:4421

miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling.
Authors: Martin Et al.
Korean J Physiol Pharmacol  2014;5:353

AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2.
Authors: Kim Et al.
J Ginseng Res  2014;38:16

Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: the role of angiotensin II, TNF-α, and MAP kinase signaling.
Authors: Wei Et al.
Am J Physiol Heart Circ Physiol  2014;307:H1643

P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells.
Authors: El-Sayed Et al.
J Cell Mol Med  2014;307:C83

Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration.
Authors: Bae Et al.
Am J Physiol Cell Physiol  2014;306:C918

ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamox. resistance in ER+ breast cancer.
Authors: Heckler Et al.
FEBS J  2014;281:2431

Decrease of PKB/Akt Phosphorylation is Partially Mediated by SAPK/JNK Activation in Serum-free L6 Myoblasts Starved with Low Glucose.
Authors: Kim Et al.
J Phys Ther Sci  2014;26:1757

Protective effect of Danggui (Radix Angelicae Sinensis) on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells.
Authors: Huang Et al.
BMC Complement Altern Med  2014;14:358

Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
Authors: Basu Et al.
Autophagy  2014;10:1193

Transcriptional regulation of an Ins-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15.
Authors: Enomoto Et al.
Am J Physiol Lung Cell Mol Physiol  2013;8:e83183

Fibroblast growth factor-4 enhances proliferation of mouse embryonic stem cells via activation of c-Jun signaling.
Authors: Kook Et al.
PLoS One  2013;8:e71641

Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes.
Authors: Stradner Et al.
Genes Cancer  2013;65:2113

The role of bioactive nanofibers in enamel regeneration mediated through integrin signals acting upon C/EBPα and c-Jun.
Authors: Huang Et al.
Biomaterials  2013;34:3303

PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.
Authors: Berdichevsky Et al.
J Neurosci  2013;33:9056

Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability.
Authors: Xiong Et al.
J Am Heart Assoc  2013;2:e000096

A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in Human Hepatoma Cells.
Authors: Suk Et al.
Evid Based Complement Alternat Med  2013;2013:658370

Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
Authors: Morse Et al.
BMC Pharmacol Toxicol  2013;14:17

Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
Authors: Schepetkin Et al.
Mol Pharmacol  2012;81:832

Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 DArgic neurons.
Authors: Lin Et al.
PLoS One  2012;7:e50138

Free fatty acid palmitate impairs the vitality and function of cultured human bladder smooth muscle cells.
Authors: Oberbach Et al.
Am J Physiol Cell Physiol  2012;7:e41026

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis.
Authors: Akhmetshina Et al.
Stem Cells Int  2012;3:735

Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D₃-enhanced duodenal calcium transport in male mice.
Authors: Khuituan Et al.
Am J Physiol Endocrinol Metab  2012;302:E903

Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells.
Authors: Chen Et al.
PLoS One  2012;16:1447

Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways.
Authors: Meotti Et al.
Br J Pharmacol  2012;166:1127

Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
Authors: Morse Et al.
PLoS One  2011;6:e25643

Mitochondrial localized STAT3 is involved in NGF induced neurite outgrowth.
Authors: Zhou and Too
Arthritis Rheum  2011;6:e21680

Reversible differentiation of myofibroblasts by MyoD.
Authors: Hecker Et al.
J Biol Chem  2011;317:1914

Dermatophagoides pteronyssinus 2 regulates nerve growth factor release to induce airway inflammation via a reactive oxygen species-dependent pathway.
Authors: Ye Et al.
J Inflamm (Lond)  2011;300:L216

JNK suppression is essential for 17β-OE inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.
Authors: Hsu Et al.
PLoS One  2011;18:61

MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways.
Authors: Kang Et al.
J Immunol  2011;187:222

Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells.
Authors: Kim Et al.
Nat Commun  2011;15:211

Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway.
Authors: Tsai Et al.
J Nutr  2011;141:2119

Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish.
Authors: Ishida Et al.
Dev Biol  2010;340:468

Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species.
Authors: Lee Et al.
Oncogene  2010;29:561

miR-155 and its star-form partner miR-155* cooperatively regulate type I IF. production by human plasmacytoid dendritic cells.
Authors: Zhou Et al.
Blood  2010;116:5885

Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension.
Authors: Wong Et al.
Circ Res  2010;107:984

c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner.
Authors: Yu Et al.
Cancer Res  2009;69:7704

AMP kinase signaling determines whether c-Jun N-terminal kinase promotes survival or apoptosis during glucose deprivation.
Authors: Yun Et al.
Carcinogenesis  2009;30:529

PHR regulates growth cone pausing at intermediate targets through microtubule disassembly.
Authors: Hendricks and Jesuthasan
J Neurosci  2009;29:6593

Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.
Authors: Yeligar Et al.
J Immunol  2009;183:5964

Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1.
Authors: Sutcliffe Et al.
Br J Pharmacol  2009;157:436

The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.
Authors: Steubesand Et al.
BMC Immunol  2009;10:36

15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription.
Authors: Su Et al.
Mol Cancer Ther  2008;7:3429

Glioma regression in vitro and in vivo by a suicide combined treatment.
Authors: García-Escudero Et al.
Exp Cell Res  2008;6:407

Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats.
Authors: Wei Et al.
Hypertension  2008;52:679

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
Authors: Jung Et al.
Carcinogenesis  2008;29:713

MAP kinases mediate interleukin-13 effects on calcium signaling in human airway smooth muscle cells.
Authors: Moynihan Et al.
Am J Physiol Lung Cell Mol Physiol  2008;295:L171

c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.
Authors: Wolter Et al.
Mol Cell Biol  2008;28:4407

Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.
Authors: Hoffmann Et al.
J Biol Chem  2008;283:12120

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway.
Authors: Chen Et al.
Blood  2008;111:4365

Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin.
Authors: Schlee Et al.
Infect Immun  2007;75:2399

Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death.
Authors: Zhou Et al.
Mol Cancer Res  2007;72:765

5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.
Authors: Su Et al.
Mol Cancer Ther  2007;6:1562

Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex.
Authors: Toyoda Et al.
Mol Pain  2007;3:36

PacT.-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.
Authors: Sunters Et al.
Cancer Res  2006;66:212

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages.
Authors: Olsson and Sundler
J Immunol  2006;3:8

PacT. (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathways.
Authors: Wang Et al.
Oncogene  2006;25:4857

Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
Authors: Guillemot and Citi
Mol Biol Cell  2006;17:3569

Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells.
Authors: Shacka Et al.
Cardiorenal Med  2006;13:1506

Transforming growth factor-beta1 regulates macrophage migration via RhoA.
Authors: Kim Et al.
Blood  2006;108:1821

Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
Authors: Kauppinen Et al.
Proc Natl Acad Sci U S A  2006;103:7136

Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats.
Authors: Lee Et al.
Toxicol Sci  2005;84:270

Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest.
Authors: Kuntzen Et al.
Cancer Res  2005;65:6780

Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma.
Authors: Yun Et al.
Blood  2005;280:9963

MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors.
Authors: Hoffmann Et al.
J Biol Chem  2005;280:9706

Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection.
Authors: Ma Et al.
PLoS One  2005;280:16208

Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid.
Authors: Zuco Et al.
Cell Death Differ  2004;11:280

Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes.
Authors: Holzberg Et al.
J Biol Chem  2003;278:40213

Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK.
Authors: Stähle Et al.
J Cell Sci  2003;116:3835

Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes.
Authors: Campàs Et al.
Cell Death Differ  2003;101:3674