Home / Adenylyl Cyclase Inhibitors / SQ 22536

SQ 22536

Catalog #: 1435
13 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1435/10
1435/50
SQ 22536 | CAS No. 17318-31-9 | Adenylyl Cyclase Inhibitors
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Description: Adenylyl cyclase inhibitor

Chemical Name: 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine

Purity: ≥99%

Product Details
Citations (13)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SQ 22536 is an inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Cell permeable.

Technical Data

M.Wt:
205.22
Formula:
C9H11N5O
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
17318-31-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SQ 22536

The citations listed below are publications that use Tocris products. Selected citations for SQ 22536 include:

13 Citations: Showing 1 - 10

  1. Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.
    Authors: Schnúr Et al.
    Sci Rep  2019;9:12706
  2. Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome.
    Authors: Costa Et al.
    Front Mol Neurosci  2018;11:353
  3. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports  2017;7:39905
  4. Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition.
    Authors: Liu Et al.
    Mol Cell Endocrinol  2016;424:118
  5. The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway.
    Authors: Olesen Et al.
    American Journal of Physiology - Renal Physiology  2016;311:F935
  6. Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition.
    Authors: Wang Et al.
    Sci.Signal.  2015;8
  7. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
    Authors: Du Et al.
    FASEB J  2015;29:2194
  8. Lactate-mediated glia-neuronal signalling in the mammalian brain.
    Authors: Tang Et al.
    Nat Commun  2014;5:3284
  9. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
    Authors: Tao Et al.
    Biochim Biophys Acta  2013;8:e71441
  10. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice.
    Authors: Babu Et al.
    J Nutr  2012;142:724

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