Home / Neurotensin Receptor Antagonists / SR 142948

SR 142948

Catalog #: 2309
4 Citations Datasheet / COA / SDS
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2309/10
2309/1
SR 142948 | CAS No. 184162-64-9 | Neurotensin Receptor Antagonists
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Description: Highly potent NTS receptor antagonist

Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid

Purity: ≥97%

Product Details
Citations (4)
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Biological Activity

SR 142948 is a potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.

Technical Data

M.Wt:
685.86
Formula:
C39H51N5O6
Solubility:
Soluble to 75 mM in DMSO and to 25 mM in water
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
184162-64-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SR 142948

The citations listed below are publications that use Tocris products. Selected citations for SR 142948 include:

4 Citations: Showing 1 - 4

  1. Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin.
    Authors: Rouibi Et al.
    J Cereb Blood Flow Metab  2016;9:470
  2. Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons.
    Authors: Piccart Et al.
    J Neurosci  2015;35:11144
  3. Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines.
    Authors: Olszewski-Hamilton and Hamilton
    Cancers (Basel)  2011;3:182
  4. Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
    Authors: Yin Et al.
    Neuropharmacology  2008;54:79

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