SU 6656
Chemical Name: 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
Purity: ≥98%
Biological Activity
SU 6656 is a potent ATP-competitive Src family kinase inhibitor (IC50 values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC50 = 0.22 μM for the α2 kinase domain). Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling.
Blake et al.
Mol.Cell Biol., 2000;20:9018 -
Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sora.
Ross et al.
Cell.Chem.Biol., 2017;24:813
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Citation for SU 6656
The citations listed below are publications that use Tocris products. Selected citations for SU 6656 include:
1 Citation: Showing 1 - 1
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GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons.
Authors: Andrii Et al.
Mov Disord 2020;35:2279-2289
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