T3
Chemical Name: O-(4-Hydroxy-3-iodophenyl-3,5-diiodo-L-tyrosine
Purity: ≥98%
Biological Activity
T3 is a thyroid hormone. Promotes differentiation of oligodendroglial precursor cells in neonatal rats and promotes maturation of hiPSC-derived cardiomyocytes. Also specifies cone cell subtype in retinal cell differentiation protocols. T3 is used in protocols to generate cortical spheroids from hPSCs.T3 synthesized to Ancillary Material Grade also available.
For more information about how T3 may be used, see our protocol: Generation of β cells from hPSCs
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Induction of myelinating oligodendrocytes in human cortical spheroids.
Madhavan et al.
Nat.Methods., 2018;15:700 -
Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system.
Marta et al.
J.Neurosci.Res., 1998;53:251 -
Tri-iodo-L-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells.
Yang et al.
J.Mol.CellCardiol., 2014;72:296 -
Thyroid hormone signaling specifies cone subtypes in human retinal organoids.
Eldred et al.
Science, 2018;362:eaau6348
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