Tandospirone hydrochloride

Catalog #: 2854 Datasheet / COA / SDS

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Tandospirone hydrochloride | CAS No. 99095-10-0 | 5-HT1 Receptor Agonists

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Description: Selective 5-HT1A partial agonist

Alternative Names: SM-3997

Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride

Purity: ≥98%

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Biological Activity

Tandospirone hydrochloride is a 5-HT_1A receptor partial agonist (K_i = 27 nM) that displays selectivity over 5-HT₂, 5-HT_1C, α₁, α₂, D₁ and D₂ receptors (K_i values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT_1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Technical Data

M.Wt:

419.95

Formula:

C₂₁H₂₉N₅O₂.HCl

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in water

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

99095-10-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites.
Hamik et al.
Biol.Psychiatry, 1990;28:99
Effects of tandospirone in three behavioral tests for anxiolytics.
Pollard et al.
Eur.J.Pharmacol., 1992;221:297
Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions.
Matsubara et al.
Brain Res., 2006;1112:126

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