TAPI 1
Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)--alanyl-L-alaninamide
Purity: ≥95%
Biological Activity
TAPI 1 is a TACE/ADAM-17 and MMP inhibitor. Blocks shedding of TNF from cell membranes. Reduces pain-associated behavior in mice with a constructive mononeuropathy.This product is typically reconstituted in DMSO.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy.
Sommer et al.
Neurosci. Lett., 1997;237:45 -
Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing.
Mohler et al.
Nature, 1994;370:218
Product Datasheets
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Citation for TAPI 1
The citations listed below are publications that use Tocris products. Selected citations for TAPI 1 include:
1 Citation: Showing 1 - 1
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Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling.
Authors: Franck Et al.
Dev Cell 2020;52:104-117.e5
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