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TB 21007

Catalog #: 2905
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2905/10
2905/50
TB 21007 | CAS No. 207306-50-1 | GABA-A Receptor Inverse Agonists
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Description: α5-selective GABAA inverse agonist

Chemical Name: 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TB 21007 is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.

Technical Data

M.Wt:
339.5
Formula:
C15H17NO2S3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
207306-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TB 21007

The citations listed below are publications that use Tocris products. Selected citations for TB 21007 include:

2 Citations: Showing 1 - 2

  1. Blockade of spinal α5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats.
    Authors: De la Luz-Cuellar Et al.
    Eur J Pharmacol  2019;858:172443
  2. Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
    Authors: Koh Et al.
    J Clin Invest  2013;64:145

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