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TCS OX2 29

Catalog #: 3371
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3371/10
3371/50
TCS OX2 29 | CAS No. 1610882-30-8 | OX2 Receptor Antagonists
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Description: Potent and selective OX2 antagonist

Chemical Name: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride

Purity: ≥98%

Product Details
Citations (9)
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Biological Activity

TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM). Displays >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

Technical Data

M.Wt:
433.97
Formula:
C23H31N3O3.HCl
Solubility:
Soluble to 100 mM in water and to 25 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
1610882-30-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCS OX2 29

The citations listed below are publications that use Tocris products. Selected citations for TCS OX2 29 include:

9 Citations: Showing 1 - 9

  1. Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice
    Authors: Bian Et al.
    Neurosci Lett  2021;765:136291
  2. The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats.
    Authors: Asadi
    BMC Neurosci  2018;19(1):49
  3. Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats.
    Authors: Zhou Et al.
    Neuropharmacology  2015;99:481
  4. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus.
    Authors: Beig Et al.
    Clin.Exp.Pharmacol.Physiol.  2015;42:1059
  5. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
    Authors: Shu Et al.
    PLoS One  2014;9:e95259
  6. A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior.
    Authors: Plaza-Zabala Et al.
    J Mol Neurosci  2013;38:1724
  7. Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.
    Authors: Brown Et al.
    Int.J.Neuropsychopharmacol.  2013;16:2067
  8. Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures.
    Authors: Urbańska Et al.
    PLoS One  2012;46:42561
  9. Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors.
    Authors: Huang Et al.
    J Pharmacol Exp Ther  2010;334:522

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