Thioflavin T
Chemical Name: 2-[4-(Dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride
Purity: ≥95%
Biological Activity
Thioflavin T is a cell-permeable fluorescent amyloid stain. This cationic benzothiazole dye increases in fluorescence upon binding to the stacked β sheets of amyloid fibrils. Thioflavin T is used to confirm formation of β sheet structure from mutant huntingtin exon-1 aggregates (Ex1Q48) in vitro. Thioflavin T is also used to monitor the kinetics of in vitro polyglutamine amyloid formation of tNhtt-42Q aggregates in a Huntington's disease cell model. Insoluble senile plaques of Aβ in brain tissues are commonly stained with Thioflavin T. Excitation/emission maxima = 440/485 nm.This product is supplied with a high degree of hydration and some residual inorganic salts, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Optical Data for Thioflavin T
| Emission Color | Blue |
|---|---|
| λabs | 440 nm |
| λem | 485 nm |
| Extinction Coefficient (ε) | 31600 M-1cm-1 |
| Quantum Yield (φ) | 0.43 |
| Cell Permeable | Yes |
| Application | amyloid stain |
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Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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