Thioridazine hydrochloride
Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Purity: ≥99%
Biological Activity
Thioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells.
Sachlos et al.
Cell., 2012;May 23.:Epub ahead of print -
Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells.
Kang et al.
Apoptosis., 2012;Mar 30:Epub ahead of print
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Citation for Thioridazine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:
1 Citation: Showing 1 - 1
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Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.
Authors: Chigaev Et al.
J Biol Chem 2011;286:5455
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