Tizanidine hydrochloride
Chemical Name: 5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
Purity: ≥99%
Biological Activity
Tizanidine hydrochloride is an α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain.
Asano et al.
Anesth.Analg., 2000;90:400 -
Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain.
Piletz et al.
Neuropsychopharmacology, 2000;23:697
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Citation for Tizanidine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Tizanidine hydrochloride include:
1 Citation: Showing 1 - 1
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Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.
Authors: Thomas C Et al.
Cell 2019;179:498-513.e22
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