Topiramate
Chemical Name: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Purity: ≥99%
Biological Activity
Topiramate is an anticonvulsant. Antagonizes GluK1 (formerly GluR5) kainate receptors (IC50 = 0.46 μM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.
Zona et al.
Neurosci.Lett., 1997;231:123 -
Topiramate as an inhibitor of carbonic anhydrase isoenzymes.
Dodgson et al.
Epilepsia, 2000;41:S35 -
Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist.
Kaminiski et al.
Neuropharmacology, 2004;46:1097 -
Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topir. in rat basolateral amygdala neurons.
Gryder and Rogawski
J.Neurosci., 2003;23:7069
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