TR 14035
Chemical Name: (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid
Purity: ≥98%
Biological Activity
TR 14035 is a potent integrin α4β7 and α4β1 antagonist (IC50 values are 7 and 87 nM, respectively). Inhibits binding of HEK 293 cells to osteopontin forms. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist.
Sircar et al.
Bioorg.Med.Chem., 2002;6:20151 -
Inhibition of cellular adhesion by immunological targeting of osteopontin neoepitopes generated through matrix metalloproteinase and thrombin cleavage.
Jürets et al.
PLoS One, 2019;11:e0148333
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