Tranilast
Chemical Name: 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Purity: ≥99%
Biological Activity
Tranilast is an antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT1 receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo.
Isaji et al.
Br.J.Pharmacol., 1997;122:1061 -
Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells.
Hishikawa et al.
J.Cardiovasc.Pharmacol., 1996;28:200 -
Regulation of calcium-permeable TRPV2 channel by Ins in pancreatic beta-cells.
Hisanaga et al.
Diabetes., 2009;58:174 -
Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.
Jin et al.
Eur.J.Pharmacol., 1998;361:199 -
Tranilast binds to Aβ monomers and promotes Aβ fibrillation.
Connors et al.
Biochemistry, 2013;
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Tranilast
There are currently no reviews for this product. Be the first to review Tranilast and earn rewards!
Have you used Tranilast?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
