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TUG 891

Catalog #: 4601
3 Citations Datasheet / COA / SDS
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4601/10
4601/50
TUG 891 | CAS No. 1374516-07-0 | Free Fatty Acid Receptor Agonists
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Description: Potent and selective FFA4 (GPR120) agonist

Chemical Name: 4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

TUG 891 is a potent FFA4 (GPR120) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

Technical Data

M.Wt:
364.41
Formula:
C23H21FO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1374516-07-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Southern Denmark.

Background References

  1. Ginsenoside-Rb2 inhibits dexamethasone-induced apoptosis through promotion of GPR120 induction in bone marrow-derived mesenchymal stem cells.
    Gao B, Huang Q, Jie Q, Zhang H, Wang L, Guo Y, Sun Z, Wei B, Han Y, Liu J, Yang L, Luo Z
    Stem Cells Dev, 2015;24(6):781-90.
  2. Docosahexaenoic acid (DHA) effects on proliferation and steroidogenesis of bovine granulosa cells
    V Maillard, A Desmarchai, M Durcin, S Uzbekova, S Elis
    Reprod. Biol. Endocrinol., 2018;16(1):40.
  3. Discovery of a potent and selective GPR120 agonist.
    Shimpukade et al.
    J.Med.Chem., 2012;55:4511
  4. The GPR120 Agonist TUG-891 Inhibits the Motility and Phagocytosis of Mouse Alveolar Macrophages
    XL Su, YG Liu, M Shi, YY Zhao, XY Liang, LJ Zhang, LL Wei, YF Zhao
    Biomed Res Int, 2020;2020(0):1706168.

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Citations for TUG 891

The citations listed below are publications that use Tocris products. Selected citations for TUG 891 include:

3 Citations: Showing 1 - 3

  1. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
    Authors: Jeremy F Et al.
    Cell  2019;179:1289-1305.e21
  2. Illuminating G-Protein-Coupling Selectivity of GPCRs.
    Authors: J Silvio Et al.
    Cell  2019;177:1933-1947.e25
  3. Docosahexaenoic acid (DHA) effects on proliferation and steroidogenesis of bovine granulosa cells.
    Authors: Maillard Et al.
    Reprod Biol Endocrinol  2018;16:40

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