UCB 35625

Catalog # Availability Size / Price Qty
2757/1
2757/10
UCB 35625 | CAS No. 202796-42-7 | Chemokine Receptor Antagonists
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Description: Potent CCR1 and CCR3 antagonist

Chemical Name: 1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

UCB 35625 is a potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50 values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM).

Isomer also available.

Technical Data

M.Wt:
655.44
Formula:
C30H37Cl2IN2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
202796-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for UCB 35625

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