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UK 370106

Catalog #: 2900
1 Citation Datasheet / COA / SDS
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2900/10
UK 370106 | CAS No. 230961-21-4 | Synthetic Metalloprotease Inhibitors
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Description: Highly selective MMP-3 and MMP-12 inhibitor

Chemical Name: (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid

Purity: ≥95%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.

Technical Data

M.Wt:
572.73
Formula:
C35H44N2O5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
230961-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers.
    Fray et al.
    J.Med.Chem., 2003;46:3514
  2. A novel series of highly selective inhibitors of MMP-3.
    Whitlock et al.
    Bioorg.Med.Chem.Letts., 2007;17:6750
  3. Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.
    Matthews et al.
    Int.J.Pharmaceutics, 2008;356:110

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Citation for UK 370106

The citations listed below are publications that use Tocris products. Selected citations for UK 370106 include:

1 Citation: Showing 1 - 1

  1. Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.
    Authors: Agren Et al.
    J Biol Chem  2015;94:44531

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