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Valinomycin

Catalog #: 3373
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3373/10
3373/50
Valinomycin | CAS No. 2001-95-8 | Ionophores
1 Image
Description: Selective K+ ionophore

Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)

Purity: ≥90%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Valinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data

M.Wt:
1111.32
Formula:
C54H90N6O18
Solubility:
Soluble to 25 mM in DMSO and to 25 mM in ethanol
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
2001-95-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum.
    Davidson and Berman
    J.Biol.Chem., 1985;260:7325
  2. Valinomycin-induced apoptosis in Chinese hamster ovary cells.
    Abdalah et al.
    Neurosci.Letts., 2006;405:68
  3. The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes.
    Rose and Jenkins
    Bioelectrochem., 2007;70:387

Product Datasheets

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Citations for Valinomycin

The citations listed below are publications that use Tocris products. Selected citations for Valinomycin include:

3 Citations: Showing 1 - 3

  1. A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.
    Authors: MacDonald Et al.
    Commun Biol  2019;2:258
  2. The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.
    Authors: Yin Et al.
    Nat Commun  2018;9:2815
  3. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
    Authors: Cassilly Et al.
    J Cancer  2016;11:e0154932

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