Home / mAChR M1 Antagonists / VU 0255035

VU 0255035

Catalog #: 3727
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3727/25
3727/5
VU 0255035 | CAS No. 1135243-19-4 | mAChR M1 Antagonists
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Description: Highly selective M1 antagonist

Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide

Purity: ≥99%

Product Details
Citations (6)
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Biological Activity

VU 0255035 is a highly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.

Technical Data

M.Wt:
432.52
Formula:
C18H20N6O3S2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1135243-19-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for VU 0255035

The citations listed below are publications that use Tocris products. Selected citations for VU 0255035 include:

6 Citations: Showing 1 - 6

  1. Cholinergic control of striatal GABAergic microcircuits.
    Authors: James M Et al.
    Cell Rep  2022;41:111531
  2. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
    Authors: Zhu Et al.
    Nat Commun  2017;8:1676
  3. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Mar Drugs  2015;9:457
  4. M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
    Authors: Urrunaga Et al.
    Proc Natl Acad Sci U S A  2015;78:66
  5. M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
    Authors: Rachakonda Et al.
    Sci Rep  2015;5:14110
  6. Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    Front Cell Neurosci  2015;112:8124

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