VU 0360172 hydrochloride

Catalog #: 4323
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4323/10
4323/50

VU 0360172 hydrochloride | CAS No. 1309976-62-2 | Group I mGluR Modulators

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Description: Positive allosteric modulator of mGlu5 receptors

Chemical Name: N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity

VU 0360172 hydrochloride is a positive allosteric modulator of mGlu₅ receptors (EC₅₀ = 16 nM; K_i = 195 nM). Selective for mGlu₅; displays no significant activity at mGlu₁, mGlu₂ or mGlu₄ receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Technical Data

M.Wt:

330.78

Formula:

C₁₈H₁₅FN₂O.HCl

Solubility:

Soluble to 50 mM in DMSO and to 25 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1309976-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Potentiation of mGlu₅ receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.
D'Amore et al.
Neuropharmacology, 2013;66:330
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Rodriguez
Mol.Pharmacol., 2010;78:1105

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Citations for VU 0360172 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for VU 0360172 hydrochloride include:

2 Citations: Showing 1 - 2

Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice.
Authors: Bogdan A Et al.
J Neurochem 2021;156:225-248
Positive modulation of mGluR5 attenuates seizures and reduces TNF-α⁺ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy.
Authors: Hanak Et al.
Exp.Neurol. 2019;311:194

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