WAY 161503 hydrochloride
Chemical Name: 8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
Purity: ≥99%
Biological Activity
WAY 161503 hydrochloride is a potent and selective 5-HT2C receptor agonist (Ki = 4 nM; EC50 = 12 nM). Shows approximately 2-fold selectivity for 5HT2C over 5HT2A in HEK293 cell lines (EC50 = 7.3 nM and 12 nM, respectively). Antidepressant following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors.
Cryan and Lucki
J.Pharmacol.Exp.Ther., 2000;295:1120 -
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines.
Welmaker et al.
Bioorg.Med.Chem.Lett., 2000;10:1991 -
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
J.Med.Chem., 2013;56:1211
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for WAY 161503 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for WAY 161503 hydrochloride include:
4 Citations: Showing 1 - 4
-
Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
Authors: Hirono
Neuropharmacology 2017;118:79
-
5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated.
Authors: Doslikova Et al.
J Neurosci 2013;33:9800
-
Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.
Authors: Banas Et al.
Neuropsychopharmacology 2011;36:423
-
Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Authors: Mbaki
Br J Pharmacol 2008;155:343
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for WAY 161503 hydrochloride
There are currently no reviews for this product. Be the first to review WAY 161503 hydrochloride and earn rewards!
Have you used WAY 161503 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
