Wiskostatin
Chemical Name: 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Purity: ≥99%
Biological Activity
Wiskostatin is an inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses.
Wegner et al.
J.Biol.Chem., 2008;283:15912 -
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Peterson et al.
Nat.Struct.Mol.Biol., 2004;11:747 -
N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels.
Guerriero and Weisz et al.
Am.J.Physiol.Cell Physiol., 2006;292:C1562
Product Datasheets
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Citations for Wiskostatin
The citations listed below are publications that use Tocris products. Selected citations for Wiskostatin include:
3 Citations: Showing 1 - 3
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Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model.
Authors: Raymond P Et al.
J Virus Erad 2022;8:100307
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A cryo-electron tomography workflow reveals protrusion-mediated shedding on injured plasma membrane.
Authors: Yogaditya Et al.
Sci Adv 2021;7
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Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF).
Authors: Rassokhin and Pakhomov
Cell Biochem Biophys 2014;69:555
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