Wortmannin

PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
Authors: Maugeri Et al.
Oncotarget  2016;7:139

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
Authors: Lee Et al.
Oncotarget  2016;7:11322

The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cellslacking functional GABA_B receptors
Authors: Olianas Et al.
European Journal of Pharmacology  2016;794:135

SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
Authors: Wilson Et al.
Sci Rep  2016;6:17735

Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
Authors: Ahmed
Physiological Reports  2016;4:e13069

Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
Authors: Li Et al.
J Clin Invest  2016;126:389

The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.
Authors: Sahay Et al.
PLoS One  2015;6:20604

Endothelial Rac1 is essential for hematogenous metastasis to the lung.
Authors: Yao Et al.
Sci Rep  2015;6:17501

Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β.
Authors: Jiang Et al.
Mol Cancer  2015;5:11765

α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Ins in Cerebellar Granule Cells.
Authors: Accardi Et al.
J Neurosci  2015;35:9676

Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
Authors: Ledonne Et al.
Mol Psychiatry  2015;20:959

Receptor protein tyrosine phosphatase β/ζ is a functional binding partner for vascular endothelial growth factor.
Authors: Koutsioumpa Et al.
Oncotarget  2015;14:19

Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Authors: Rogers and Gahring
Front Pharmacol  2015;10:e0143319

Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
Authors: Jiang and Zsombok
Front Neurosci  2014;7:270

Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.
Authors: Ruisanchez Et al.
FASEB J  2014;28:880

Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na.
Authors: Mäki-Jouppila Et al.
Nat Commun  2014;13:1054

Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes.
Authors: Takada Et al.
J Cell Sci  2014;127:4159

A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
Authors: Mitrugno Et al.
Blood  2014;123:249

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.
Authors: McAlpine Et al.
Autophagy  2013;9:361

Combination of LC3 shRNA plasmid transfection and genistein treatment inhibited autophagy and increased apoptosis in malignant neuroblastoma in cell culture and animal models.
Authors: Mohan Et al.
PLoS One  2013;8:e78958

Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy.
Authors: Stefanidou Et al.
Mol Immunol  2013;87:1443

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity.
Authors: Choi Et al.
J Virol  2013;4:2383

An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
Authors: Siddoway Et al.
J Pharmacol Exp Ther  2013;33:11206

Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.
Authors: Faria Et al.
Am J Physiol Endocrinol Metab  2013;305:E230

Cellular Ins resistance disrupts leptin-mediated control of neuronal signaling and transcription.
Authors: Nazarians-Armavil Et al.
Mol Endocrinol  2013;27:990

HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression.
Authors: Cheshenko Et al.
FASEB J  2013;27:2584

The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res  2013;14:134

The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention.
Authors: Chen Et al.
BMC Vet Res  2012;8:73

Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
Authors: Villers Et al.
PLoS One  2012;7:e40823

Endogenous urotensin II selectively modulates erectile function through eNOS.
Authors: Bianca Et al.
PLoS One  2012;7:e31019

An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Authors: Khurana Et al.
J Neurosci  2012;32:2814

TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury.
Authors: Yin Et al.
J Cell Sci  2012;238:93

CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
Authors: Roselli Et al.
PLoS One  2011;6:e23097

Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci  2010;30:6080

FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model.
Authors: Liu Et al.
Am J Physiol Endocrinol Metab  2010;299:E351

Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
Authors: Roselli Et al.
PLoS One  2009;4:e6011

FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
Authors: Grodzki Et al.
Exp Neurol  2009;46:2539

Inhibitory effect of ETB receptor on Na(+)-K(+) ATPase activity by extracellular Ca(2+) entry and Ca(2+) release from the endoplasmic reticulum in renal proximal tubule cells.
Authors: Liu Et al.
Hypertens Res  2009;32:846

c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells.
Authors: Garcia Et al.
J Immunol  2009;183:4475

Kinase networks integrate profiles of N-MthD.-aspartate receptor-mediated gene expression in hippocampus.
Authors: Coba Et al.
J Biol Chem  2008;283:34101

Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses.
Authors: Garcia Et al.
J Immunol  2008;181:8363

The novel adipocytokine visfatin exerts direct cardioprotective effects.
Authors: Lim Et al.
J Cell Mol Med  2008;12:1395

Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.
Authors: Nelson Et al.
J Neurochem  2008;107:602

IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
Authors: Chung Et al.
J Endocrinol  2007;194:77

Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel.
Authors: Rojas Et al.
Biochim Biophys Acta  2007;1768:2030

PI-3-kinase-dependent membrane recruitment of centaurin-α2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation.
Authors: Venkateswarlu Et al.
J Neurosci  2007;120:792

GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.
Authors: Lin Et al.
J Cell Sci  2007;120:2935

Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum.
Authors: Bianca Et al.
J Cell Biochem  2006;316:703

Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors.
Authors: O'Riordan Et al.
J Neurosci  2006;26:4870

Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.
Authors: Qiu Et al.
Mol Cancer Ther  2006;26:12943

Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons.
Authors: Tokuoka and Goda
J Neurosci  2006;26:11606

LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II.
Authors: Searl and Silinsky
Purinergic Signal  2005;1:389

Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro.
Authors: Schlemper Et al.
Br J Pharmacol  2005;145:740