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Xamoterol hemifumarate

Catalog #: 0950
10 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0950/10
0950/50
Xamoterol hemifumarate | CAS No. 73210-73-8 | Adrenergic beta-1 Receptor Agonists
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Description: Selective β1 partial agonist
Alternative Names: ICI 118,587

Chemical Name: 1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate

Purity: ≥97%

Product Details
Citations (10)
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Biological Activity

Xamoterol hemifumarate is a β1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors respectively).

Technical Data

M.Wt:
397.43
Formula:
C16H25N3O5.0.5C4H4O4
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at RT
CAS No:
73210-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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Citations for Xamoterol hemifumarate

The citations listed below are publications that use Tocris products. Selected citations for Xamoterol hemifumarate include:

10 Citations: Showing 1 - 10

  1. Adrenergic modulation of AMPK-dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer.
    Authors: Zhi Et al.
    Int J Oncol  2019;54:1625
  2. Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes.
    Authors: Picard Et al.
    Commun Biol  2018;1:106
  3. β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
    Authors: Lavine
    Invest Ophthalmol Vis Sci  2017;58(1):299
  4. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
    Authors: Creed Et al.
    Breast Cancer Res  2015;17:145
  5. Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
    Authors: Copik Et al.
    J Pharmacol Exp Ther  2015;10:e0115701
  6. Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
    Authors: Lavine Et al.
    JAMA Ophthalmol  2013;131:376
  7. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  8. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J  2011;25:4486
  9. β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation.
    Authors: Steinle Et al.
    PLoS One  2003;278:20681
  10. Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes.
    Authors: Skeberdis Et al.
    Br J Pharmacol  1997;121:1277

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