Home / Na+/Ca2+ Exchanger Inhibitors / YM 244769

YM 244769

Catalog #: 4544
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4544/10
4544/50
YM 244769 | CAS No. 1780390-65-9 | Na+/Ca2+ Exchanger Inhibitors
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Description: Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

Chemical Name: N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Technical Data

M.Wt:
516.39
Formula:
C26H22FN3O3.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1780390-65-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for YM 244769

The citations listed below are publications that use Tocris products. Selected citations for YM 244769 include:

5 Citations: Showing 1 - 5

  1. Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells.
    Authors: Xiaoli Et al.
    Int J Mol Sci  2022;23
  2. Activation of Glutamate Transport Increases Arteriole Diameter in v ivo: Implications for Neurovascular Coupling.
    Authors: Hajime Et al.
    Front Cell Neurosci  2022;16:831061
  3. The cellular prion protein interacts with and promotes the activity of Na,K-ATPases.
    Authors: Mohadeseh Et al.
    PLoS One  2021;16:e0258682
  4. Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death.
    Authors: Yan Et al.
    Br J Pharmacol  2019;176:2691-2707
  5. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
    Authors: O'Donnell Et al.
    J Neurosci  2016;36:7109

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