Home / Additional RTK Inhibitors / ZAP 180013

ZAP 180013

Catalog #: 6821 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6821/10
6821/50
ZAP 180013 | CAS No. 873080-25-2 | Additional RTK Inhibitors
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Description: Zap70 inhibitor; inhibits interaction with ITAMs

Chemical Name: 5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide

Purity: ≥98%

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Biological Activity

ZAP 180013 is a zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.

Technical Data

M.Wt:
454.32
Formula:
C19H17Cl2N3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
873080-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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