Home / Methyltransferase Inhibitors / Zebularine

Zebularine

Catalog #: 2293
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2293/10
Zebularine | CAS No. 3690-10-6 | Methyltransferase Inhibitors
1 Image
Description: DNA methyltransferase and cytidine deaminase inhibitor
Alternative Names: NSC 309132

Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Zebularine is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.

Technical Data

M.Wt:
228.2
Formula:
C9H12N2O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
3690-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
    Laliberte et al.
    Cancer Chemother.Pharmacol., 1992;30:7
  2. Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
    Ben-Kasus et al.
    Biochem.Pharmacol., 2005;70:121
  3. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
    Naeem et al.
    Cardiovasc.Ther. [Epub ahead of print], 2012;

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Zebularine

The citations listed below are publications that use Tocris products. Selected citations for Zebularine include:

4 Citations: Showing 1 - 4

  1. The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation.
    Authors: Zou Et al.
    Front Immunol  2019;10:1950
  2. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One  2013;8:e72881
  3. DNA methylation mediates the discriminatory power of associative long-term memory in honeybees.
    Authors: Biergans Et al.
    PLoS One  2012;7:e39349
  4. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
    Authors: Trowbridge Et al.
    Gastroenterology  2012;26:344

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Zebularine

There are currently no reviews for this product. Be the first to review Zebularine and earn rewards!

Have you used Zebularine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.